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With the combination of image segmentation between white and gray matter and cerebrospinal fluid, signal compensation of T, and T<jats:sub>2<\/jats:sub> effects, tissue water signal as the internal concentration reference, as well as compensation by different water contents in gray and white matters, it was determined that the levels of N\u2010acetylaspartate (NAA), creatine and\/or phosphocreatine (Cr), and choline\u2010containing compounds (Cho) in gray matter were significantly higher than in white matter. The averaged NAA, Cr, and Cho concentrations in gray matter were 11.0, 9.7, and 1.9 mM\/liter, respectively, in comparison with 7.5, 5.2, and 1.6 mM\/liter in white matter. 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