{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:36:51Z","timestamp":1761237411510},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,13]],"date-time":"2005-12-13T00:00:00Z","timestamp":1134432000000},"content-version":"vor","delay-in-days":2903,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fluorine (<jats:sup>19<\/jats:sup>F) magnetic resonance spectroscopy (MRS) was used to quantify the combined concentration of the anorectic drug dexfenfluramine (DF) and its active metabolite d\u2010norfenfluramine (dNF) in rhesus monkey brain. The accuracy of the MRS technique was assessed by comparison with gas chromatography. Brain <jats:sup>19<\/jats:sup>F MRS signals were converted to brain DF + dNF concentrations after correction for signal relaxation losses and drug distribution in nonbrain tissue. Gas chromatography (GC) was used to assay brain DF and dNF concentrations following MRS evaluation. DF + dNF concentrations measured by <jats:sup>19<\/jats:sup>F MRS averaged 104 \u00b1 36 <jats:italic>\u03bcM<\/jats:italic> (mean \u00b1 SD) and GC measurements averaged 71 \u00b1 12 <jats:italic>\u03bcM.<\/jats:italic> Correction for the distribution of DF and its metabolites in nonbrain tissue yielded a DF + metabolite brain concentration that was within one standard deviation of the GC\u2010derived value. The concentration of DF plus dNF measured by <jats:sup>19<\/jats:sup>F MRS was similar to or greater than the value obtained by GC, which indicates that DF and its active metabolite dNF are fully detected by <jats:sup>19<\/jats:sup>F MRS in primate brain <jats:italic>in vivo.<\/jats:italic> The application of these techniques to human subjects should enable the measurement of low micromolar\u2010range brain concentrations of DF and other fluorinated drugs.<\/jats:p>","DOI":"10.1002\/mrm.1910390121","type":"journal-article","created":{"date-parts":[[2007,3,13]],"date-time":"2007-03-13T13:09:05Z","timestamp":1173791345000},"page":"149-154","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Quantitation of dexfenflurainine\/d\u2010norfenfluramine concentration in primate brain using <sup>19<\/sup>F NMR spectroscopy"],"prefix":"10.1002","volume":"39","author":[{"given":"James D.","family":"Christensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzann M.","family":"Babb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce M.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perry F.","family":"Renshaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/55.2.495s"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"508S","DOI":"10.1093\/ajcn\/55.2.508s","article-title":"Morbidity of severely obese subjects","volume":"55","author":"Sjostrom L. 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