{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:10:20Z","timestamp":1785499820426,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":2751,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[1998,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cerebral apparent diffusion coefficients {ADCs) were determined in nine newborn piglets before and for 48 h after transient hypoxia\u2010ischemia. Phosphorus MRS revealed severely reduced cerebral energy metabolism during the insult and an apparently complete recovery 2 h after resuscitation commenced. At this time, mean ADC over the imaging slice (ADC<jats:sub>global<\/jats:sub>) was 0.88 (0.04) \u00d7 10<jats:sup>\uf8ff9<\/jats:sup> m<jats:sup>2<\/jats:sup> \u00b7 s<jats:sup>\uf8ff1<\/jats:sup> (mean (SD}), which was close to the baseline value of 0.92 (0.4) \u00d7 10<jats:sup>\uf8ff9<\/jats:sup> m<jats:sup>2<\/jats:sup> \u00b7 s<jats:sup>\uf8ff1<\/jats:sup>. In seven of the animals, a \u201csecondary\u201d failure of energy metabolism then evolved, accompanied by a decline in ADC<jats:sub>global<\/jats:sub> to 0.64 (0.17) \u00d7 10<jats:sup>\uf8ff9<\/jats:sup> m<jats:sup>2<\/jats:sup> \u00b7 s<jats:sup>\uf8ff1<\/jats:sup> at 46 h postresuscitation (<jats:italic>P &lt;<\/jats:italic> 0.001 versus baseline). For these seven animals, ADC<jats:sub>global<\/jats:sub> correlated linearly with the concentration ratio [phosphocreatine (PCr)][inorganic phosphate (Pi)] (0.94 <jats:italic>r &lt;<\/jats:italic> 0.99; <jats:italic>P &gt;<\/jats:italic> 0.001). A nonlinear relationship was demonstrated between ADC<jats:sub>global<\/jats:sub>, and the concentration ratio [nucleotide triphosphate (NTP)]\/ [Pi + PCr + 3 NTP]. The ADC reduction commenced in the parasagittal cortex before spreading in a characteristic pattern throughout the brain. ADC seems to be closely related to cerebral energy status and shows considerable potential for the assessment of hypoxic\u2010ischemic injury in the newborn brain.<\/jats:p>","DOI":"10.1002\/mrm.1910390609","type":"journal-article","created":{"date-parts":[[2007,3,13]],"date-time":"2007-03-13T22:34:40Z","timestamp":1173825280000},"page":"920-927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Temporal and anatomical variations of brain water apparent diffusion coefficient in perinatal cerebral hypoxic\u2010ischemic injury: Relationships to cerebral energy metabolism"],"prefix":"10.1002","volume":"39","author":[{"given":"John S.","family":"Thornton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger J.","family":"Ordidge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliet","family":"Penrice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest B.","family":"Cady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip N.","family":"Amess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shonit","family":"Punwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Clemence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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