{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T04:39:39Z","timestamp":1698554379578},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":2690,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[1998,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Proton\u2010electron double\u2010resonance imaging (PEDRI) was used to assess renal function by monitoring the flow of the exogenous nitroxide free radical proxyl carboxylic acid (PCA) through normal and injured kidneys in the living rat. Kidney damage was induced by treatment with 2\u2010bromoethylamine (BEA), which provides a well established model for human analgesic nephropathy. PCA clearance rates for liver, abdominal blood vessels, and renal tissues were determined from serial PEDRI images of normal rats (<jats:italic>n<\/jats:italic> = 6) and rats treated with BEA (<jats:italic>n<\/jats:italic> = 21). Different groups of BEA\u2010treated animals were imaged on day 4 (<jats:italic>n<\/jats:italic> = 6), day 6 (<jats:italic>n<\/jats:italic> = 6), and day 9 (<jats:italic>n<\/jats:italic> = 9) after treatment. In BEA\u2010treated rats, there was an increase in PCA half\u2010life in all tissues studied. This increase was greatest in the kidney tissues and the effect progressed with time after treatment. The effect is probably due to BEA\u2010induced damage to the tubules in the renal cortex and may not be related to the primary lesions in the renal medulla.<\/jats:p>","DOI":"10.1002\/mrm.1910400214","type":"journal-article","created":{"date-parts":[[2007,3,14]],"date-time":"2007-03-14T01:09:37Z","timestamp":1173834577000},"page":"280-286","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Chemically induced analgesic nephropathy in the rat monitored by proton\u2010electron double\u2010resonance imaging (PEDRI)"],"prefix":"10.1002","volume":"40","author":[{"given":"Ioannis","family":"Seimenis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret A.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Lurie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M. 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