{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:16:15Z","timestamp":1761822975858},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":2659,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[1998,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Functional mapping of the rat somatosensory cortex was performed with <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>*\u2010sensitized MRI using a forepaw electrical stimulation model in \u03b1\u2010chloralose\u2010anesthetized rats at 7 T under both normocapnia and mild hyperventilation\u2010induced hypocapnia. A highly localized activation area, consistent with the known somatosensory cortical region, was detected in all seven animals studied during hypocapnia and in five of the same animals during normocapnia. Quantitatively, hypocapnia was found to significantly increase both the size of the fMRl activation area (3.4 \u00b1 0.6 mm<jats:sup>2<\/jats:sup> versus 1.5 \u00b1 0.6 mm<jats:sup>2<\/jats:sup> in normocapnia, mean \u00b1 standard error, <jats:italic>n<\/jats:italic> = 7, <jats:italic>P<\/jats:italic> &lt; 0.03) and the average fMRl signal intensity increase (3.4 \u00b1 0.6% versus 2.7 \u00b1 0.4%, <jats:italic>n<\/jats:italic> = 5, <jats:italic>P<\/jats:italic> &lt; 0.05). The increased sensitivity of fMRl to functional activation may reflect a widened arterial\u2010venous oxygenation difference resulting from an increased effective oxygen extraction during hyperventilation. The dependence of the fMRl response on the ventilation state underscores the need to control for physiological parameters in animal fMRl studies.<\/jats:p>","DOI":"10.1002\/mrm.1910400312","type":"journal-article","created":{"date-parts":[[2007,3,14]],"date-time":"2007-03-14T02:34:59Z","timestamp":1173839699000},"page":"421-426","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Functional MRI of the rat somatosensory cortex: Effects of hyperventilation"],"prefix":"10.1002","volume":"40","author":[{"given":"Edward W.","family":"Hsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence W.","family":"Hedlund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"MacFall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1984.60.5.0883"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.24.9868"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910250220"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.12.5675"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.13.5951"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1992.tb03474.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1994.81"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.1.475"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910360104"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1984.51.5.1109"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910140108"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910220117"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104359"},{"key":"e_1_2_1_15_2","first-page":"1","article-title":"Histology by magnctic resonance microscopy","volume":"9","author":"Johnson G. 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