{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:42:27Z","timestamp":1773290547848,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,11,23]],"date-time":"2004-11-23T00:00:00Z","timestamp":1101168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bone marrow cells (BMC) labeled with iron particles can be injected into the heart and detected with MRI. Improvement in conspicuity of labelled cells would be advantageous. This study examined if double contrast with iron oxide and Gd\u2010DTPA enhances cell MRI after transvascular transplantation in myocardial infarction. Ten pigs with week\u2010old myocardial infarction had transvascular peri\u2010infarct delivery of microspheres alone (Group I, <jats:italic>n<\/jats:italic> = 3) or mixed with iron\u2010labeled BMCs (Group II, <jats:italic>n<\/jats:italic> = 7). Gradient\u2010echo MRI before and 1 min after systemic Gd\u2010DTPA administration produced regions of interest with hypoenhancement that were compared to contralateral regions for contrast\u2010to\u2010noise (CNR) and signal\u2010to\u2010noise (SNR) ratios. All hearts were harvested for gross and microscopic analysis. Areas of focal hypoenhancement corresponding to the BMCs were detected in the myocardium in Group II. Early after administration of Gd\u2010DTPA CNR increased from 17.58 \u00b1 8.5 to 27.25 \u00b1 15.8 (<jats:italic>P<\/jats:italic> &lt; 0.05) and SNR from 24.87 \u00b1 9.6 to 35.08 \u00b1 15.5 (<jats:italic>P<\/jats:italic> &lt; 0.05). There was no hypoenhancement in Group I. Tissue examination confirmed presence of iron\u2010containing cells and microspheres in corresponding segments of the heart. The distribution of microspheres was similar between the groups. Double contrast with cellular iron and Gd\u2010DTPA in surrounding myocardium resulted in improved cell localization by MRI. Magn Reson Med 52:1438\u20131442, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrm.20292","type":"journal-article","created":{"date-parts":[[2004,11,23]],"date-time":"2004-11-23T21:49:18Z","timestamp":1101246558000},"page":"1438-1442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Novel double contrast MRI technique for intramyocardial detection of percutaneously transplanted autologous cells"],"prefix":"10.1002","volume":"52","author":[{"given":"Dmitri V.","family":"Baklanov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebo D.","family":"Demuinck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig A.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin D.","family":"Pearlman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11,23]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"AHA.Heart disease and stroke statistics\u20142003 update.American Heart Association;2003."},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1993.1085"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00414-5"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000070931.62772.4E"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000084537.66419.7A"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/21.7.537"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1076-6332(96)80597-6"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.12.3318"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200012)44:6<909::AID-MRM12>3.0.CO;2-U"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.20292","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.20292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:08:39Z","timestamp":1697155719000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.20292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,23]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1002\/mrm.20292"],"URL":"https:\/\/doi.org\/10.1002\/mrm.20292","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,23]]},"assertion":[{"value":"2003-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-04-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-11-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}