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The purpose of this initial study was to combine the LASER localization sequence with fast 3D echo\u2010planar imaging (EPI) to quantify the regional apparent transverse relaxation (T<jats:sub>2<\/jats:sub><jats:sup>\u2020<\/jats:sup>) in a rabbit model of acute embolic ischemia at 4 Tesla. Carr\u2010Purcell T<jats:sub>2<\/jats:sub><jats:sup>\u2020<\/jats:sup>\u2010weighted images were acquired at 7 different echo\u2010times and used to estimate T<jats:sub>2<\/jats:sub><jats:sup>\u2020<\/jats:sup> in both cortex and striatum. In ischemic tissue identified by 2,3,5 \u2010 triphenyltetrazolium chloride (TTC) staining, the T<jats:sub>2<\/jats:sub><jats:sup>\u2020<\/jats:sup> increased by approximately 31% after 1 hour of ischemia and remained elevated until study completion at 4 h of ischemia. Lesion volume, defined as the number of pixels with T<jats:sub>2<\/jats:sub><jats:sup>\u2020<\/jats:sup> greater than 90 ms, increased by 40% between 1 and 4 h after induction of ischemia. Carr\u2010Purcell LASER\u2010EPI T<jats:sub>2<\/jats:sub><jats:sup>\u2020<\/jats:sup>\u2010weighted images show promise in detecting early tissue changes in focal cerebral ischemia. 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