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Decoupling imposes significant constraints on the experimental setup (particularly for human studies at high magnetic field) in order to stay within safety limits for power deposition. We show here that incorporation of the <jats:sup>13<\/jats:sup>C label from <jats:sup>13<\/jats:sup>C\u2010labeled glucose into brain amino acids can be monitored accurately using localized <jats:sup>13<\/jats:sup>C NMR spectroscopy <jats:italic>without<\/jats:italic> the application of <jats:sup>1<\/jats:sup>H decoupling. Using LCModel quantification with prior knowledge of one\u2010bond and multiple\u2010bond J<jats:sub>CH<\/jats:sub> coupling constants, the uncertainty on metabolites concentrations was only 35% to 91% higher (depending on the carbon resonance of interest) in undecoupled spectra compared to decoupled spectra in the rat brain at 9.4 Tesla. Although less sensitive, <jats:sup>13<\/jats:sup>C NMR without decoupling dramatically reduces experimental constraints on coil setup and pulse sequence design required to keep power deposition within safety guidelines. This opens the prospect of safely measuring <jats:sup>13<\/jats:sup>C NMR spectra in humans at varied brain locations (not only the occipital lobe) and at very high magnetic fields above 4 Tesla. Magn Reson Med, 2006. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrm.20756","type":"journal-article","created":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T20:13:11Z","timestamp":1134418391000},"page":"279-286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Investigating brain metabolism at high fields using localized <sup>13<\/sup>C NMR spectroscopy without <sup>1<\/sup>H decoupling"],"prefix":"10.1002","volume":"55","author":[{"given":"Dinesh Kumar","family":"Deelchand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e2mil","family":"U\u011furbil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Gilles","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.841"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","unstructured":"de GraafRA MasonGF PatelAB BeharKL RothmanDLIn vivo1H\u2010[13C]\u2010NMR spectroscopy of cerebral metabolism.NMR Biomed.2003;16:339\u2013357.","DOI":"10.1002\/nbm.847"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2003.08.014"},{"key":"e_1_2_6_5_2","unstructured":"Criteria for significant risk investigations of magnetic resonance diagnostic devices\u2014guidance for industry and FDA staff. 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