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Efficacious treatment of interstitial tumors with PDT requires efficient delivery of photosensitizers and accurate location of tumor tissues for effective light irradiations. In this study we performed contrast\u2010enhanced (CE) MRI\u2010guided PDT with a bifunctional polymer conjugate containing both a magnetic resonance imaging (MRI) contrast agent and a photosensitizer, poly(<jats:italic>L<\/jats:italic>\u2010glutamic acid) (PGA)\u2010(Gd\u2010DO3A)\u2010mesochlorin e<jats:sub>6<\/jats:sub> (Mce<jats:sub>6<\/jats:sub>). The efficacy of the bifunctional conjugate in cancer CE\u2010MRI and cancer treatment was evaluated in athymic nude mice bearing MDA\u2010MB\u2010231 human breast carcinoma xenografts, with PGA\u2010(Gd\u2010DO3A) used as a control. The polymer conjugates preferentially accumulated in the solid tumor due to the hyperpermeability of the tumor vasculature, resulting in significant tumor enhancement for accurate tumor detection and localization by MRI. Significant therapeutic response was observed for PDT with the bifunctional conjugate as compared to the control. CE\u2010MRI\u2010guided PDT with the bifunctional conjugate is effective for tumor detection and minimally invasive cancer treatment. Magn Reson Med, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrm.21009","type":"journal-article","created":{"date-parts":[[2006,8,10]],"date-time":"2006-08-10T17:48:31Z","timestamp":1155232111000},"page":"761-767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Contrast enhanced MRI\u2010guided photodynamic therapy for site\u2010specific cancer 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