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In this study the feasibility of performing reliable EPRI\/MRI fusion imaging using nitroxyl radical fiducial markers was tested. The pharmacokinetics of the nitroxyl radicals were observed after oral or intravenous administration in C57BL6 mice. To fuse both images, the nitroxyl radical was used as fiducial markers. The EPR and MR images corresponded well and clearly illustrated minimal changes in pharmacokinetics between carbamoyl\u2010PROXYL and carboxy\u2010PROXYL. These results demonstrate that the EPRI\/MRI fused imaging technique is useful for investigating in vivo pharmacokinetics and provides unambiguous anatomic details. 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