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Due to the biexponential <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> decay of the tissue Na signal with a short component, which ranges between 0.5\u20138 ms, the measurement of total Na content requires imaging techniques with echo times (TEs) below 0.5 ms. A 3D radial pulse sequence with a TE of 0.2 ms at a spatial resolution of 4 \u00d7 4 \u00d7 4 mm<jats:sup>3<\/jats:sup> was developed that allows the acquisition and presentation of Na images on the scanner. This sequence was evaluated in patients with low\u2010 and high\u2010grade gliomas, and higher <jats:sup>23<\/jats:sup>Na MR signals corresponding to an increased Na content were found in the tumor regions. The contrast\u2010to\u2010noise ratio (CNR) between tumor and white matter increased from 0.8 \u00b1 0.2 to 1.3 \u00b1 0.3 with tumor grade. In patients with an identified muscular <jats:sup>23<\/jats:sup>Na channelopathy (Paramyotonia congenita (PC)), induced muscle weakness led to a signal increase of \u223c18% in the <jats:sup>23<\/jats:sup>Na MR images, which was attributed to intracellular Na<jats:sup>+<\/jats:sup> accumulation in this region. 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