{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T18:09:12Z","timestamp":1775153352846,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,10,29]],"date-time":"2007-10-29T00:00:00Z","timestamp":1193616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multiple pairs of adiabatic passage pulses were implemented in a spin\u2010echo sequence to achieve accurate measurements of the apparent transverse relaxation time (<jats:italic>T<\/jats:italic><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-stack-2.gif\" xlink:title=\"urn:x-wiley:07403194:media:MRM21373:tex2gif-stack-2\"\/>) in a short scan time. In experiments on agarose gel phantoms with <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> values ranging from 30 to 105 ms, the measured <jats:italic>T<\/jats:italic><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-stack-3.gif\" xlink:title=\"urn:x-wiley:07403194:media:MRM21373:tex2gif-stack-3\"\/> values were in good agreement with transverse relaxation times measured with a nonselective Carr\u2010Purcell\u2010Meiboom\u2010Gill sequence. In experiments on normal human brain at 4.7 T, <jats:italic>T<\/jats:italic><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-stack-4.gif\" xlink:title=\"urn:x-wiley:07403194:media:MRM21373:tex2gif-stack-4\"\/> values in five different gray matter regions were found to range from 38 \u00b1 2 ms (globus pallidus) to 64 \u00b1 2 ms (frontal cortex). The apparent relaxation rate (1\/<jats:italic>T<\/jats:italic><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-stack-5.gif\" xlink:title=\"urn:x-wiley:07403194:media:MRM21373:tex2gif-stack-5\"\/>) in these five regions showed strong correlation (<jats:italic>r<\/jats:italic> = 0.97) with published levels of iron (Fe) in those regions. The linear coefficient relating 1\/<jats:italic>T<\/jats:italic><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-stack-6.gif\" xlink:title=\"urn:x-wiley:07403194:media:MRM21373:tex2gif-stack-6\"\/> and [Fe] at 4.7 T was measured to be 0.551 (s \u00b7 mg Fe\/100 g f.w.)<jats:sup>\u22121<\/jats:sup>. When compared with the values obtained in a previous report for six different static fields (<jats:italic>B<\/jats:italic><jats:sub>0<\/jats:sub>) up to 1.5 T, the current measurement confirms the linear dependence of the linear coefficient on <jats:italic>B<\/jats:italic><jats:sub>0<\/jats:sub> up to 4.7 T (<jats:italic>r<\/jats:italic> = 0.99). These results suggest that the <jats:italic>T<\/jats:italic><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-stack-7.gif\" xlink:title=\"urn:x-wiley:07403194:media:MRM21373:tex2gif-stack-7\"\/> value in the human brain is predominantly affected by the nonhemin iron distribution. The strong correlation between the obtained <jats:italic>T<\/jats:italic><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-stack-8.gif\" xlink:title=\"urn:x-wiley:07403194:media:MRM21373:tex2gif-stack-8\"\/> values and the regional iron concentrations suggests a role for this pulse sequence in quantifying in vivo brain iron at high magnetic field. Magn Reson Med 58:1054\u20131060, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrm.21373","type":"journal-article","created":{"date-parts":[[2007,10,29]],"date-time":"2007-10-29T21:13:05Z","timestamp":1193692385000},"page":"1054-1060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Apparent transverse relaxation rate in human brain varies linearly with tissue iron concentration at 4.7 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