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The use of <jats:sup>1<\/jats:sup>H to <jats:sup>31<\/jats:sup>P polarization transfer can improve the sensitivity using a refocused INEPT method with a potential enhancement of 2.4 (\u03b3<jats:sub>1H<\/jats:sub>\/\u03b3<jats:sub>31P<\/jats:sub>). However, in this method the <jats:sup>31<\/jats:sup>P signals of PE, PC, GPE, and GPC are strongly attenuated (50% or more) due to J\u2010coupling between <jats:sup>31<\/jats:sup>P and <jats:sup>1<\/jats:sup>H that have similar magnitudes for homonuclear J\u2010coupling constants in those metabolites. A method to cancel the homonuclear J\u2010coupling effects in polarization transfer experiments is to apply frequency\u2010selective refocusing pulses, which becomes feasible at 3T due to the increased chemical shift dispersion as compared to 1.5T. In this study, full <jats:sup>1<\/jats:sup>H to <jats:sup>31<\/jats:sup>P polarization transfer was realized using chemical shift selective refocusing pulses at 3T. <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> and <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> values for <jats:sup>1<\/jats:sup>H and <jats:sup>31<\/jats:sup>P spins of PE, PC, GPE, and GPC were measured in the human brain. A more than 2\u2010fold signal\u2010to\u2010noise ratio (SNR) improvement was obtained compared to an optimized direct <jats:sup>31<\/jats:sup>P MRS method. As shifted RF pulses were used, this method can be applied on a broadband clinical MR system with a single RF system. Magn Reson Med 60:1298\u20131305, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrm.21733","type":"journal-article","created":{"date-parts":[[2008,11,24]],"date-time":"2008-11-24T18:57:21Z","timestamp":1227553041000},"page":"1298-1305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Efficient <sup>1<\/sup>H to <sup>31<\/sup>P polarization transfer on a clinical 3T MR system"],"prefix":"10.1002","volume":"60","author":[{"given":"D.W.J.","family":"Klomp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.P.","family":"Wijnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.W.J.","family":"Scheenen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Heerschap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,11,24]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2006.08.003"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1492(199911)12:7<413::AID-NBM587>3.0.CO;2-U"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1940050518"},{"key":"e_1_2_7_5_2","first-page":"3286","article-title":"Metabolic characterization of human non\u2010Hodgkin's lymphomas in vivo with the use of proton\u2010decoupled phosphorus magnetic resonance spectroscopy","volume":"55","author":"Negendank WG","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1057"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10367"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-341-7_13"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/mp060067e"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1940010405"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910330316"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20659"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910370228"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10551"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20745"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1208"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.464850"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1492(200005)13:3<129::AID-NBM619>3.0.CO;2-V"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.713"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1110"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(85)90400-X"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(91)90248-R"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.21733","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.21733","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.21733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T20:43:09Z","timestamp":1696884189000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.21733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,24]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["10.1002\/mrm.21733"],"URL":"https:\/\/doi.org\/10.1002\/mrm.21733","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,24]]},"assertion":[{"value":"2007-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-05-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-11-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}