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The phantom contained a specifically designed poly(ethylene oxide)\/poly(methyl methacrylate) (PEO\/PMMA) blend, whose MRI properties (<jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>, <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>, and resonance linewidth) were similar to those of solid bone matrix (collagen, tightly bound water, and other immobile molecules), minimizing the need to correct for differences in <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> and\/or <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> relaxation between the phantom and the subject. Cortical and trabecular porcine bone specimens were imaged using WASPI with the calibration phantom in the field of view (FOV) as a stable intensity reference. Gravimetric and amino acid analyses were carried out on the same specimens after WASPI, and the chemical results were found to be highly correlated (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 0.98 and 0.95, respectively) to the WASPI intensity. By this procedure the WASPI intensity can be used to obtain the true bone matrix mass density in <jats:italic>g<\/jats:italic> cm<jats:sup>\u20133<\/jats:sup>. Magn Reson Med 60:1433\u20131443, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrm.21771","type":"journal-article","created":{"date-parts":[[2008,11,24]],"date-time":"2008-11-24T18:57:21Z","timestamp":1227553041000},"page":"1433-1443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Quantitative bone matrix density measurement by water\u2010 and fat\u2010suppressed proton projection MRI (WASPI) with polymer calibration phantoms"],"prefix":"10.1002","volume":"60","author":[{"given":"Haihui","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome L.","family":"Ackerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko I.","family":"Hrovat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lila","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin J.","family":"Glimcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaotang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,11,24]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00460-X"},{"key":"e_1_2_7_3_2","first-page":"154","volume-title":"Bone and joint imaging","author":"Sartoris DJ","year":"1996"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.02.022"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.02.016"},{"key":"e_1_2_7_6_2","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s002239900471","article-title":"Evaluation of bone mineral density using three dimensional solid state phosphorus\u201031 NMR projection imaging","volume":"62","author":"Wu Y","year":"1998","journal-title":"Calcif Tissue Int"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.4.1574"},{"key":"e_1_2_7_8_2","unstructured":"WuY AckermanJL CheslerDA WangJ GlimcherMJ.In vivo solid state31P MRI of human tibia at 1.5 T. 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