{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:59:06Z","timestamp":1769835546455,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,12,18]],"date-time":"2008-12-18T00:00:00Z","timestamp":1229558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 DK66084-01"],"award-info":[{"award-number":["R01 DK66084-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Magnetic resonance <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>* has been validated as a noninvasive means of assessing myocardial iron overload. However, the effect on myocardial <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>* of factors such as shimming, variations in capillary geometry, and susceptibility in relation to the effects of iron has not been fully clarified. Since <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> is not affected by extrinsic magnetic field inhomogeneity and has different sensitivity to capillary geometry, investigation into the in vivo relationship between myocardial <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>* and <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> measurements can shed light on this important issue. This study was performed in 136 thalassemia patients. The myocardial <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> and <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>* thresholds for normality created identical no\u2010iron\u2010overload and iron\u2010overloaded patient groups. In the no\u2010iron group, there was no correlation between myocardial <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> and <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>*. In the iron\u2010overloaded patients, there was a linear correlation (R<jats:sup>2<\/jats:sup> = 0.89) between myocardial <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>* and <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> measurements, which indicates that the iron deposition is the dominant factor in determining these two relaxation values in this scenario. Magn Reson Med, 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrm.21874","type":"journal-article","created":{"date-parts":[[2008,12,25]],"date-time":"2008-12-25T01:38:14Z","timestamp":1230169094000},"page":"501-506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["On using <i>T<\/i><sub>2<\/sub> to assess extrinsic magnetic field inhomogeneity effects on <i>T<\/i><sub>2<\/sub>* measurements in myocardial siderosis in thalassemia"],"prefix":"10.1002","volume":"61","author":[{"given":"Taigang","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian C.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D.","family":"Gatehouse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raad 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