{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:21:23Z","timestamp":1791166883613,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Short <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> species such as the Achilles tendon and cortical bone cannot be imaged with conventional MR sequences. They have a much broader absorption lineshape than long <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> species, therefore they are more sensitive to an appropriately placed off\u2010resonance irradiation. In this work, a technique termed ultrashort TE (UTE) with off\u2010resonance saturation contrast (UTE\u2010OSC) is proposed to image short <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> species. A high power saturation pulse was placed +1 to +2 kHz off the water peak to preferentially saturate signals from short <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> species, leaving long <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> water and fat signals largely unaffected. The subtraction of UTE images with and without an off\u2010resonance saturation pulse effectively suppresses long <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> water and fat signals, creating high contrast for short <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> species. The UTE\u2010OSC technique was validated on a phantom, and applied to bone samples and healthy volunteers on a clinical 3T scanner. High\u2010contrast images of the Achilles tendon and cortical bone were generated with a high contrast\u2010to\u2010noise ratio (CNR) of the order of 12 to 20 between short <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> and long <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> species within a total scan time of 4 to 10 min. Magn Reson Med, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrm.22007","type":"journal-article","created":{"date-parts":[[2009,5,16]],"date-time":"2009-05-16T02:08:24Z","timestamp":1242439704000},"page":"527-531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Ultrashort TE imaging with off\u2010resonance saturation contrast (UTE\u2010OSC)"],"prefix":"10.1002","volume":"62","author":[{"given":"Jiang","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi M.","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Bydder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine B.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme M.","family":"Bydder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910330406"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/crad.2003.1157"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910100113"},{"key":"e_1_2_5_5_2","first-page":"903","article-title":"Pulsed magnetization transfer imaging: evaluation of technique","volume":"199","author":"Graham SJ","journal-title":"Radiology"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.683"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910290209"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340221"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199912)42:6<1128::AID-MRM18>3.0.CO;2-9"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.179.3.2027991"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(88)90131-X"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340502"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-200311000-00001"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2007.08.005"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20926"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(87)90085-0"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2004.09.004"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1078\/0939-3889-00315"},{"key":"e_1_2_5_19_2","unstructured":"DuJ TakahashiA ChungCB BydderGM.Ultrshort TE (UTE) Imaging with off\u2010resonance saturation: creating high contrast for short T2tissues. In: Proceedings of the 16th Annual Meeting of ISMRM Toronto Ontario Canada 2008(Abstract 3639)."},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20605"},{"key":"e_1_2_5_21_2","first-page":"343","article-title":"Musculoskeletal MRI at 3.0T: relaxation times and image contrast","volume":"183","author":"Gold GE","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20808"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.22007","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.22007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.22007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T12:58:46Z","timestamp":1697461126000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.22007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,15]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["10.1002\/mrm.22007"],"URL":"https:\/\/doi.org\/10.1002\/mrm.22007","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,15]]},"assertion":[{"value":"2008-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-02-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-05-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}