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Renally impaired animals had more activity associated with their tissues than did control mice, and this increase varied according to the radiotracer injected. For example, after 7 days, renally impaired animals that received <jats:sup>153\/Nat<\/jats:sup>Gd\u2010DOTA had 3\u2010fold (<jats:italic>P<\/jats:italic> &lt; 0.037) more activity in their bone tissue, whereas renally impaired animals receiving <jats:sup>153\/Nat<\/jats:sup>Gd\u2010DTPA and <jats:sup>153\/Nat<\/jats:sup>Gd\u2010DTPA\u2010BMA had 8\u2010fold (<jats:italic>P<\/jats:italic> &lt; 0.0001) and 24\u2010fold (<jats:italic>P<\/jats:italic> &lt; 0.0001) more activity in their bone tissue, respectively. These findings demonstrate that renal impairment dramatically alters the tissue distribution of Gd<jats:sup>3+<\/jats:sup> ions in vivo, which are likely a critical factor in the development of nephrogenic systemic fibrosis. 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