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Choline and citrate (Cit) signals were measured in prostate lesions and normal\u2010appearing peripheral zone as identified on <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>\u2010weighted images. Metabolites were quantified relative to unsuppressed water from a separately acquired magnetic resonance spectroscopic imaging dataset using LCModel. Validation experiments were also performed in a phantom containing physiological concentrations of choline, Cit, and creatine. In vitro, fair agreement between measured and true concentrations was observed, with the greatest discrepancy being a 35% underestimation of Cit. In vivo, one dataset was rejected for failure to meet the quality criterion of linewidth &lt;15 Hz, and in 6 of 15 subjects, insufficient normal\u2010appearing peripheral zone tissue was identified for study. Lesions were found to have higher choline and choline\/Cit, and lower Cit, than normal\u2010appearing peripheral zone. 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