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Using small voxel sizes between 16 and 32 \u03bcl to avoid partial volume effects, most metabolites demonstrated significant regional differences except acetate, \u03b3\u2010aminobutyric acid, and phosphorylcholine. Noticeable regional differences in metabolite concentrations were the significant increase of total creatine in the cerebellum and the substantial decrease of taurine in thalamus and medulla oblongata. In particular, the glycine concentration in the medulla oblongata was determined to be 4.37 \u00b1 0.68 \u03bcmol\/g (Cram\u00e9r\u2010Rao lower bounds 7%) and thus significantly higher than in the other regions, consistent with findings reported in both in vivo <jats:sup>1<\/jats:sup>H NMR spectroscopy and in vitro biochemical assays. Intraindividual reproducibility and interindividual variability were investigated by acquiring spectra from the thalamus of the same rats in two sessions. No prominent influence on measurement session was observed in metabolite concentrations with coefficients of variations being below 20% in 16 metabolites. 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