{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T04:24:48Z","timestamp":1793766288273,"version":"4.6.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,7,11]],"date-time":"2011-07-11T00:00:00Z","timestamp":1310342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["BTRC P41 RR008079"],"award-info":[{"award-number":["BTRC P41 RR008079"]}]},{"name":"NIH","award":["NCC P30 NS057091"],"award-info":[{"award-number":["NCC P30 NS057091"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Accurate quantification of <jats:sup>1<\/jats:sup>H NMR spectra often requires knowledge of the relaxation times to correct for signal losses due to relaxation and saturation. In human brain, <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> values for singlets such as <jats:italic>N<\/jats:italic>\u2010acetylaspartate, creatine, and choline have been reported, but few <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> values are available for <jats:italic>J<\/jats:italic>\u2010coupled spin systems. The purpose of this study was to measure the <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> relaxation times of <jats:italic>J<\/jats:italic>\u2010coupled metabolites in the human occipital lobe using the LASER sequence. Spectra were acquired at multiple echo times and were analyzed with an LCModel using basis sets simulated at each echo time. Separate basis spectra were used for resonances of protons belonging to the same molecule but having very different <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> values (e.g., two separate basis spectra were used for the singlet and multiplet signal in <jats:italic>N<\/jats:italic>\u2010acetylaspartate). The <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> values for the <jats:italic>N<\/jats:italic>\u2010acetylaspartate multiplet (149 \u00b1 12 ms), glutamate (125 \u00b1 10 ms), <jats:italic>myo<\/jats:italic>\u2010inositol (139 \u00b1 20 ms), and taurine (196 \u00b1 28 ms) were successfully measured in the human visual cortex at 4 T. These measured <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> relaxation times have enabled the accurate and absolute quantification of cerebral metabolites at longer echo times. Magn Reson Med, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrm.23080","type":"journal-article","created":{"date-parts":[[2011,7,11]],"date-time":"2011-07-11T18:03:38Z","timestamp":1310407418000},"page":"891-897","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Measurement of transverse relaxation times of <i>J<\/i>\u2010coupled metabolites in the human visual cortex at 4 T"],"prefix":"10.1002","volume":"67","author":[{"given":"Dinesh 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