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Pharmacological MRI methods can elucidate the regional cerebral effects of <jats:italic>l<\/jats:italic>\u2010THP, but there are potential confounds from the use of general anesthesia. To investigate the possible anesthetic\u2013drug interactions for the pharmacological MRI result of acute <jats:italic>l<\/jats:italic>\u2010THP, we examined acute blood oxygen level\u2010dependent responses of both 5 and 20 mg\/kg <jats:italic>l<\/jats:italic>\u2010THP in na\u00efve rats during general anesthesia achieved with three agents: isoflurane, medetomidine, and urethane. We found that with acute <jats:italic>l<\/jats:italic>\u2010THP administration, isoflurane revealed the smallest blood oxygen level\u2010dependent activation areas. In addition, urethane had the most activation areas; however, they were all negative. Medetomidine showed mixed positive and negative activations. Region\u2010specific interactions were found between the <jats:italic>l<\/jats:italic>\u2010THP\u2010induced blood oxygen level\u2010dependent responses and the anesthetic agents. Magn Reson Med, 2012. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/mrm.23243","type":"journal-article","created":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T18:31:39Z","timestamp":1325097099000},"page":"552-559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Differential effect of isoflurane, medetomidine, and urethane on BOLD responses to acute levo\u2010tetrahydropalmatine in the rat"],"prefix":"10.1002","volume":"68","author":[{"given":"Xiping","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony G.","family":"Hudetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010Jiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)01929-5"},{"key":"e_1_2_6_3_2","unstructured":"JinGZ.Discoveries in the voyage of corydalis research. 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