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In this study, we have developed a rapid diffusion\u2010prepared fast imaging with steady\u2010state free precession MRI acquisition for a preclinical 7T scanner providing diffusion\u2010weighted images in less than 500 ms and diffusion tensor imaging assessments in \u223c1 min with minimal image artifacts in comparison with EPI. Phantom apparent diffusion coefficient (ADC) and fractional anisotropy (FA) assessments obtained from the diffusion\u2010prepared fast imaging with steady\u2010state free precession (DP\u2010FISP) acquisition resulted in good agreement with EPI and spin echo diffusion methods. The mean apparent diffusion coefficient was 2.0 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s, 1.90 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s, and 1.97 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s for DP\u2010FISP, diffusion\u2010weighted spin echo, and diffusion\u2010weighted EPI, respectively. The mean fractional anisotropy was 0.073, 0.072, and 0.070 for diffusion\u2010prepared fast imaging with steady\u2010state free precession, diffusion\u2010weighted spin echo, and diffusion\u2010weighted EPI, respectively. Initial <jats:italic>in vivo<\/jats:italic> studies show reasonable ADC values in a normal mouse brain and polycystic rat kidneys. Magn Reson Med, 2012. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/mrm.23287","type":"journal-article","created":{"date-parts":[[2011,12,3]],"date-time":"2011-12-03T17:56:17Z","timestamp":1322934977000},"page":"868-873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Diffusion\u2010prepared fast imaging with steady\u2010state free precession (DP\u2010FISP): A rapid diffusion MRI technique at 7 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