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The latter were also compared in terms of sensitivity to changes in oxygenation as well as of signal\u2010to\u2010noise ratio for accurate <jats:italic>p<\/jats:italic>O<jats:sub>2<\/jats:sub> measurements. For that purpose, mouse muscles were imaged at 11.7 T, at 2\u2010 and 36\u2010h after intramuscular injection of HFB or 15C5. Histological analysis of the muscle tissue revealed a lack of toxicity for 15C5 from 2 up to 36\u2010h postinjection, whereas HFB induced tissue necrosis, blood clots and thrombosis as soon as 24\u2010h postinjection. This muscle toxicity led to a limitation in mice mobility 24\u2010h after injection of HFB as evidenced by behavioral testing (open\u2010field, grip strength, and catwalk tests), which was not the case after 15C5 intramuscular injection. Finally, <jats:italic>p<\/jats:italic>O<jats:sub>2<\/jats:sub> measurements assessed 2\u2010h postinjection showed consistent values with both probes, evidencing cross\u2010validation of the <jats:sup>19<\/jats:sup>F MRI oximetry technique for acute measurements. However, the measurement at 36\u2010h was hampered for HFB, which showed significant lower values of muscle <jats:italic>p<\/jats:italic>O<jats:sub>2<\/jats:sub>, whereas 15C5 was able to reliably assess muscle <jats:italic>p<\/jats:italic>O<jats:sub>2<\/jats:sub> at 36\u2010h postinjection. Magn Reson Med, 2013. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/mrm.24245","type":"journal-article","created":{"date-parts":[[2012,3,23]],"date-time":"2012-03-23T10:36:06Z","timestamp":1332498966000},"page":"248-254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Hexafluorobenzene in comparison with perfluoro\u201015\u2010crown\u20105\u2010ether for repeated monitoring of oxygenation using <sup>19<\/sup>F MRI in a mouse 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