{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:58:03Z","timestamp":1791341883691,"version":"4.3.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T00:00:00Z","timestamp":1338336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"SNSF","doi-asserted-by":"crossref","award":["3100A0-131087"],"award-info":[{"award-number":["3100A0-131087"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Centre d'Imagerie BioM\u00e9dicale (CIBM) of the UNIL, UNIGE, HUG, CHUV, and EPFL and the Leenaards and Jeantet Foundations"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p>\n                    Proton\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    relaxation times of metabolites in the human brain have not previously been published at 7 T. In this study,\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    values of CH\n                    <jats:sub>3<\/jats:sub>\n                    and CH\n                    <jats:sub>2<\/jats:sub>\n                    group of\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetylaspartate and total creatine as well as nine other brain metabolites were measured in occipital white matter and gray matter at 7 T using an inversion\u2010recovery technique combined with a newly implemented semi\u2010adiabatic spin\u2010echo full\u2010intensity acquired localized spectroscopy sequence (echo time = 12 ms). The mean\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    values of metabolites in occipital white matter and gray matter ranged from 0.9 to 2.2 s. Among them, the\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    of glutathione, scyllo\u2010inositol, taurine, phosphorylethanolamine, and\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetylaspartylglutamate were determined for the first time in the human brain. Significant differences in\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    between white matter and gray matter were found for water (\u221228%), total choline (\u221214%),\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetylaspartylglutamate (\u221229%),\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetylaspartate (+4%), and glutamate (+8%). An increasing trend in\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    was observed when compared with previously reported values of\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetylaspartate (CH\n                    <jats:sub>3<\/jats:sub>\n                    ), total creatine (CH\n                    <jats:sub>3<\/jats:sub>\n                    ), and total choline at 3 T. However, for\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetylaspartate (CH\n                    <jats:sub>3<\/jats:sub>\n                    ), total creatine, and total choline, no substantial differences compared to previously reported values at 9.4 T were discernible. The\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    values reported here will be useful for the quantification of metabolites and signal\u2010to\u2010noise optimization in human brain at 7 T. Magn Reson Med 69:931\u2013936, 2013. \u00a9 2012 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/mrm.24352","type":"journal-article","created":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T10:25:37Z","timestamp":1338373537000},"page":"931-936","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["Proton\n                    <i>T<\/i>\n                    <sub>1<\/sub>\n                    relaxation times of metabolites in human occipital white and gray matter at 7 T"],"prefix":"10.1002","volume":"69","author":[{"given":"Lijing","family":"Xin","sequence":"first","affiliation":[{"name":"Department of Radiology University of Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Schaller","sequence":"additional","affiliation":[{"name":"Laboratory of Functional and Metabolic Imaging Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Mlynarik","sequence":"additional","affiliation":[{"name":"Laboratory of Functional and Metabolic Imaging Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanxiang","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Surgical Technologies and Biomechanics University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Gruetter","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Lausanne Lausanne Switzerland"},{"name":"Laboratory of Functional and Metabolic Imaging Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne Lausanne Switzerland"},{"name":"Department of Radiology University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1213"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2010.06.006"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1660"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.596111"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.713"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910320504"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10640"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199901)41:1<204::AID-MRM29>3.0.CO;2-7"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.857"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21043"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21961"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1492(199712)10:8<423::AID-NBM488>3.0.CO;2-X"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199904)41:4<649::AID-MRM2>3.0.CO;2-G"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(200002)43:2<319::AID-MRM22>3.0.CO;2-1"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910290613"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.811268"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910300604"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1205"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1492(200005)13:3<129::AID-NBM619>3.0.CO;2-V"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10135"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1727"},{"key":"e_1_2_6_24_1","unstructured":"SteinseiferIK MekleR GruetterR ScheenenTW HeerschapA.Implementation of GOIA\u2010Wurst pulse in a SPECIAL localization sequence at 7T. 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