{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:11:54Z","timestamp":1790165514673,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T00:00:00Z","timestamp":1353369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>The aim of this study was to quantify changes in thoracic aortic wall shear stress (WSS) in asymptomatic patients with Marfan syndrome (MFS) compared with healthy controls. WSS in the thoracic aorta was quantified based on time\u2010resolved 3D phase contrast MRI with three\u2010directional velocity encoding (4D flow MRI, temporal resolution \u223c44 ms, spatial resolution \u223c2.5 mm) in 24 patients with confirmed MFS (age = 18 \u00b1 12 years) and in 12 older healthy volunteers (age = 25 \u00b1 3 years). Diameters of the thoracic aorta normalized to body surface area were similar for both groups. Peak systolic velocity, absolute WSS, time\u2010averaged WSS, circumferential WSS, peak systolic WSS, and WSS eccentricity were calculated in eight analysis planes distributed along the thoracic aorta. Plane\u2010wise comparison revealed significant differences between MFS patients and volunteers in the proximal ascending aorta for peak systolic velocities (1.11 \u00b1 0.23 m\/s vs. 1.34 \u00b1 0.18 m\/s, <jats:italic>P<\/jats:italic> = 0.004) and circumferential WSS (0.14 \u00b1 0.03 N\/m<jats:sup>2<\/jats:sup> vs. 0.11 \u00b1 0.02 N\/m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic> = 0.007). WSS eccentricity was altered in most of the ascending aorta and proximal arch (<jats:italic>P<\/jats:italic> = 0.009\u20130.020). MFS patients demonstrated segmental differences in peak systolic WSS with a significantly higher WSS at the inner curvature in the proximal ascending aorta and at the anterior part in the more distal ascending aorta (<jats:italic>P<\/jats:italic> &lt; 0.01). These findings indicate differences in WSS associated with MFS despite similar aortic dimensions compared to controls. Magn Reson Med, 70:1137\u20131144, 2013. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/mrm.24562","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T16:31:19Z","timestamp":1353429079000},"page":"1137-1144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Aortic wall shear stress in Marfan syndrome"],"prefix":"10.1002","volume":"70","author":[{"given":"Julia","family":"Geiger","sequence":"first","affiliation":[{"name":"Department of Radiology, Medical Physics University Medical Center Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease and Pediatric Cardiology University Medical Center Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Herzer","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease and Pediatric Cardiology University Medical Center Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Hirtler","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease and Pediatric Cardiology University Medical Center Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran","family":"Stankovic","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical Physics University Medical Center Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Russe","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical Physics University Medical Center Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Langer","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical Physics University Medical Center Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Markl","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Engineering Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201851"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2007.10.001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197204132861502"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.06.094"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.081638"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20018"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.110.958504"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22383"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(95)70102-8"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21082"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-10-30"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22083"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e3182034fc2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2011.05.004"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-009-9854-3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.10.042"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2004.08.056"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-5884(98)80244-X"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21778"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21790"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.21.2035"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000091648"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.521617"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.fluid.40.111406.102126"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.106.481234"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21861"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-010-9949-x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2005.06.008"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22485"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.09091437"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.02.062"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23500"},{"key":"e_1_2_6_34_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/(SICI)1096-8628(19960424)62:4<417::AID-AJMG15>3.0.CO;2-R","article-title":"Revised diagnostic criteria for the Marfan syndrome","volume":"62","author":"Paepe A","year":"1996","journal-title":"Am J Med Genet"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.072785"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-13-7"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880030315"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910390218"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22199"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)03236-2"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1098"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.12.026"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22519"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.24562","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.24562","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T02:46:05Z","timestamp":1696473965000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.24562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,20]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1002\/mrm.24562"],"URL":"https:\/\/doi.org\/10.1002\/mrm.24562","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,20]]},"assertion":[{"value":"2012-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}