{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:26:35Z","timestamp":1760984795849},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To introduce a pulse sequence that obtains whole\u2010brain perfusion measurements at 1.7 mm isotropic voxel resolution by dynamic susceptibility contrast MRI bolus tracking despite using a temporal resolution of 10.3 s: RAdial kZ\u2010blipped 3D GRE\u2010echo\u2010planar imaging (GRE\u2010EPI) for whole\u2010brain pERfusion (RAZER).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In RAZER, in\u2010plane radial and through\u2010plane 3D GRE\u2010EPI Cartesian sampling was used to produce a 3D stack\u2010of\u2010stars <jats:italic>k<\/jats:italic>\u2010space. In vivo scans on one healthy volunteer and one patient with Moyamoya disease were performed using RAZER and a typical 2D GRE\u2010EPI pulse sequence as a reference standard. Agreement in perfusion metrics was reported using linear regression analysis and Bland\u2010Altman plots.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sliding window reconstruction recovered dynamic information lost in the large temporal acquisition window of RAZER. Inline phase correction scans corrected <jats:italic>N<\/jats:italic>\/2 ghosting artifacts and view\u2010dependent phase variations. Whole\u2010brain images of cerebral blood volume, cerebral blood flow, and mean transit time were calculated with RAZER at 1.7 mm isotropic voxel resolution and good reference standard agreement in both subjects when sliding window reconstruction was used (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> &gt; 0.7, mean bias in mean transit time measurements &lt; 0.5 s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite using a temporal resolution of 10.3 s, in vivo data indicates that RAZER is able to obtain whole\u2010brain perfusion measurements at 1.7 mm isotropic voxel resolution and good reference standard agreement. 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