{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:44:03Z","timestamp":1791420243035,"version":"4.3.3"},"reference-count":63,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T00:00:00Z","timestamp":1378252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Oxford Biomedical Research Centre"},{"DOI":"10.13039\/501100000265","name":"the Medical Research Council","doi-asserted-by":"crossref","award":["G0900883"],"award-info":[{"award-number":["G0900883"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000265","name":"the Medical Research Council","doi-asserted-by":"crossref","award":["G0700796"],"award-info":[{"award-number":["G0700796"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Merton College"},{"name":"Wellcome Trust and the Royal Society","award":["098436\/Z\/12\/Z"],"award-info":[{"award-number":["098436\/Z\/12\/Z"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2014,8]]},"abstract":"\n Purpose<\/jats:title>\n \n Phosphorus magnetic resonance spectroscopy (\n 31<\/jats:sup>\n P\u2010MRS) affords unique insight into cardiac energetics but has a low intrinsic signal\u2010to\u2010noise ratio (SNR) in humans. Theory predicts an increased\n 31<\/jats:sup>\n P\u2010MRS SNR at 7T, offering exciting possibilities to better investigate cardiac metabolism. We therefore compare the performance of human cardiac\n 31<\/jats:sup>\n P\u2010MRS at 7T to 3T, and measure T\n 1<\/jats:sub>\n s for\n 31<\/jats:sup>\n P metabolites at 7T.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Matched\n 31<\/jats:sup>\n P\u2010MRS data were acquired at 3T and 7T, on nine normal volunteers. A novel Look\u2010Locker CSI acquisition and fitting approach was used to measure T\n 1<\/jats:sub>\n s on six normal volunteers.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n T\n 1<\/jats:sub>\n s in the heart at 7T were: phosphocreatine (PCr) 3.05 \u00b1 0.41s, \u03b3\u2010ATP 1.82 \u00b1 0.09s, \u03b1\u2010ATP 1.39 \u00b1 0.09s, \u03b2\u2010ATP 1.02 \u00b1 0.17s and 2,3\u2010DPG (2,3\u2010diphosphoglycerate) 3.05 \u00b1 0.41s (N = 6). In the field comparison (N = 9), PCr SNR increased 2.8\u00d7 at 7T relative to 3T, the Cramer\u2010R\u00e1o uncertainty (CRLB) in PCr concentration decreased 2.4\u00d7, the mean CRLB in PCr\/ATP decreased 2.7\u00d7 and the PCr\/ATP SD decreased 2\u00d7.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Cardiac\n 31<\/jats:sup>\n P\u2010MRS at 7T has higher SNR and the spectra can be quantified more precisely than at 3T. Cardiac\n 31<\/jats:sup>\n P T\n 1<\/jats:sub>\n s are shorter at 7T than at 3T. We predict that 7T will become the field strength of choice for cardiac\n 31<\/jats:sup>\n P\u2010MRS. Magn Reson Med 72:304\u2013315, 2014. \u00a9 2013 The Authors. Magnetic Resonance in Medicine Published by Wiley Periodicals, Inc. on behalf of International Society of Medicine in Resonance. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mrm.24922","type":"journal-article","created":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T17:23:09Z","timestamp":1378315389000},"page":"304-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":111,"title":["Human cardiac\n 31<\/sup>\n P magnetic resonance spectroscopy at 7 tesla"],"prefix":"10.1002","volume":"72","author":[{"given":"Christopher T.","family":"Rodgers","sequence":"first","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research (OCMR) University of Oxford Level 0, John Radcliffe Hospital Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research (OCMR) University of Oxford Level 0, John Radcliffe Hospital Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Snyder","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research University of Minnesota 2021 Sixth Street SE Minneapolis Minnesota USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Thomas","family":"Vaughan","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research University of Minnesota 2021 Sixth Street SE Minneapolis Minnesota USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Neubauer","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research (OCMR) University of Oxford Level 0, John Radcliffe Hospital Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Robson","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research (OCMR) University of Oxford Level 0, John Radcliffe Hospital Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,4]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Encyclopedia of magnetic resonance","author":"Bottomley PA","year":"2009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra063052"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-397018-3.00003-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio1158"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.4023711"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.823187"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.069518"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2011.08.002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.71.847.9771379"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470512968"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v2.i1.37"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1350"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1255"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1794"},{"key":"e_1_2_7_16_1","first-page":"65","volume-title":"Preliminary 7 Tesla human cardiac 31P magnetic resonance spectroscopy [MChem]","author":"Clarke WT","year":"2012"},{"key":"e_1_2_7_17_1","unstructured":"SchroederJL TylerDJ EmmanuelY RobsonMD Scheuermann\u2010FreestoneM NeubauerS ClarkeK.Effect of patient orientation on cardiac 31P\u2010MRS. 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