{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T15:28:46Z","timestamp":1776353326871,"version":"3.51.2"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T00:00:00Z","timestamp":1381795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the feasibility of three\u2010dimensional (3D) single breath\u2010hold late gadolinium enhancement (LGE) of the left ventricle (LV) using supplemental oxygen and hyperventilation and compressed\u2010sensing acceleration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Breath\u2010hold metrics [breath\u2010hold duration, diaphragmatic\/LV position drift, and maximum variation of R wave to R wave (RR) interval] without and with supplemental oxygen and hyperventilation were assessed in healthy adult subjects using a real\u2010time single shot acquisition. Ten healthy subjects and 13 patients then underwent assessment of the proposed 3D breath\u2010hold LGE acquisition (field of view\u2009=\u2009320 \u00d7 320 \u00d7 100 mm<jats:sup>3<\/jats:sup>, resolution\u2009=\u20091.6 \u00d7 1.6 \u00d7 5.0 mm<jats:sup>3<\/jats:sup>, acceleration rate of 4) and a free\u2010breathing acquisition with right hemidiaphragm navigator (NAV) respiratory gating. Semiquantitative grading of overall image quality, motion artifact, myocardial nulling, and diagnostic value was performed by consensus of two blinded observers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Supplemental oxygenation and hyperventilation increased the breath\u2010hold duration (35\u2009\u00b1\u200911 s to 58\u2009\u00b1\u200921 s; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0125) without significant impact on diaphragmatic\/LV position drift or maximum variation of RR interval (both <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.01). LGE images were of similar quality when compared with free\u2010breathing acquisitions, but with reduced total scan time (85\u2009\u00b1\u200922 s to 35\u2009\u00b1\u20096 s; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Supplemental oxygenation and hyperventilation allow for prolonged breath\u2010holding and enable single breath\u2010hold 3D accelerated LGE with similar image quality as free breathing with NAV. Magn Reson Med 72:850\u2013857, 2014. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.24969","type":"journal-article","created":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T16:35:43Z","timestamp":1381854943000},"page":"850-857","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["3D late gadolinium enhancement in a single prolonged breath\u2010hold using supplemental oxygenation and hyperventilation"],"prefix":"10.1002","volume":"72","author":[{"given":"S\u00e9bastien","family":"Roujol","sequence":"first","affiliation":[{"name":"Department of Medicine (Cardiovascular Division) Beth Israel Deaconess Medical Center and Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamer A.","family":"Basha","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiovascular Division) Beth Israel Deaconess Medical 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