{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:09Z","timestamp":1786978389291,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,10,23]],"date-time":"2013-10-23T00:00:00Z","timestamp":1382486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The limiting factor for MRI of skeletal\/mineralized tissue is fast transverse relaxation. A recent advancement in MRI technology, SWIFT (Sweep Imaging with Fourier Transform), is emerging as a new approach to overcome this difficulty. Among other techniques like UTE, ZTE, and WASPI, the application of SWIFT technology has the strong potential to impact preclinical and clinical imaging, particularly in the context of primary or metastatic bone cancers because it has the added advantage of imaging water in mineralized tissues of bone allowing MRI images to be obtained of tissues previously visible only with modalities such as computed tomography (CT). The goal of the current study is to examine the feasibility of SWIFT for the assessment of the prostate cancer induced changes in bone formation (osteogenesis) and destruction (osteolysis) in ex vivo specimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A luciferase expressing prostate cancer cell line (PAIII) or saline control was inoculated directly into the tibia of 6\u2010week\u2010old immunocompromised male mice. Tumor growth was assessed weekly for 3 weeks before euthanasia and dissection of the tumor bearing and sham tibias. The ex vivo mouse tibia specimens were imaged with a 9.4 Tesla (T) and 7T MRI systems. SWIFT images are compared with traditional gradient\u2010echo and spin\u2010echo MRI images as well as CT and histological sections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SWIFT images with nominal resolution of 78 \u03bcm are obtained with the tumor and different bone structures identified. Prostate cancer induced changes in the bone microstructure are visible in SWIFT images, which is supported by spin\u2010echo, high resolution CT and histological analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SWIFT MRI is capable of high\u2010quality high\u2010resolution ex vivo imaging of bone tumor and surrounding bone and soft tissues. Furthermore, SWIFT MRI shows promise for in vivo bone tumor imaging, with the added benefits of nonexposure to ionizing radiation, quietness, and speed. Magn Reson Med 72:858\u2013863, 2014. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.24979","type":"journal-article","created":{"date-parts":[[2013,10,23]],"date-time":"2013-10-23T13:18:48Z","timestamp":1382534328000},"page":"858-863","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Rapid ex vivo imaging of PAIII prostate to bone tumor with SWIFT\u2010MRI"],"prefix":"10.1002","volume":"72","author":[{"given":"Ihor","family":"Luhach","sequence":"first","affiliation":[{"name":"Departments of Cancer Imaging and Metabolism H. Lee Moffitt Cancer Center and Research Institute Tampa Florida USA"},{"name":"Department of Mathematics &amp; Statistics University of South Florida Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djaudat","family":"Idiyatullin","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor C.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Tumor Biology H. Lee Moffitt Cancer Center and Research Institute Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curt","family":"Corum","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary V.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Departments of Cancer Imaging and Metabolism H. Lee Moffitt Cancer Center and Research Institute Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Garwood","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Gillies","sequence":"additional","affiliation":[{"name":"Departments of Cancer Imaging and Metabolism H. 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