{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:50:53Z","timestamp":1777614653384,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,4,14]],"date-time":"2014-04-14T00:00:00Z","timestamp":1397433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Center for Research Resources and the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health","award":["P41EB015908"],"award-info":[{"award-number":["P41EB015908"]}]},{"name":"National Center for Research Resources and the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health","award":["DK081186"],"award-info":[{"award-number":["DK081186"]}]},{"name":"National Center for Research Resources and the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health","award":["R37-HL-034557"],"award-info":[{"award-number":["R37-HL-034557"]}]},{"name":"National Center for Research Resources and the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health","award":["P01DK058398"],"award-info":[{"award-number":["P01DK058398"]}]},{"name":"National Center for Research Resources and the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health","award":["RO1AR050597"],"award-info":[{"award-number":["RO1AR050597"]}]},{"name":"Department of Defense Grant","award":["W81XWH-06-2-0046"],"award-info":[{"award-number":["W81XWH-06-2-0046"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To develop an inversion pulse\u2010based, chemical exchange saturation transfer\u2010like method for detection of <jats:sup>31<\/jats:sup>P magnetization exchanges among all nuclear magnetic resonance visible metabolites suitable for providing an integrated kinetic analysis of phosphorus exchange reactions in vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The exchange kinetics by inversion transfer (EKIT) sequence includes application of a frequency\u2010selective inversion pulse arrayed over the range of relevant <jats:sup>31<\/jats:sup>P frequencies, followed by a constant delay and a hard readout pulse. A series of EKIT spectra, each given by a plot of <jats:italic>Z<\/jats:italic>\u2010magnetization for each metabolite of interest versus frequency of the inversion pulse, can be generated from this single data set.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>EKIT spectra reflect chemical exchange due to known biochemical reactions, cross\u2010relaxation effects, and relayed magnetization transfers due to both processes. The rate constants derived from EKIT data collected on resting human skeletal muscle were: ATP synthesis via ATP synthase (0.050\u2009\u00b1\u20090.016 s<jats:sup>\u22121<\/jats:sup>), ATP synthesis via creatine kinase (0.264\u2009\u00b1\u20090.023 s<jats:sup>\u22121<\/jats:sup>), and cross\u2010relaxation between neighboring spin pairs within ATP (0.164\u2009\u00b1\u20090.022 s<jats:sup>\u22121<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>EKIT provides a simple, alternative method to detect chemical exchange, cross relaxation, and relayed magnetization transfer effects in human skeletal muscle at 7 T. <jats:bold>Magn Reson Med 73:1359\u20131369, 2015. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.25256","type":"journal-article","created":{"date-parts":[[2014,4,14]],"date-time":"2014-04-14T13:13:27Z","timestamp":1397481207000},"page":"1359-1369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Exchange kinetics by inversion transfer: Integrated analysis of the phosphorus metabolite kinetic exchanges in resting human skeletal muscle at 7 T"],"prefix":"10.1002","volume":"73","author":[{"given":"Jimin","family":"Ren","sequence":"first","affiliation":[{"name":"Advanced Imaging Research Center University of Texas Southwestern Medical Center Dallas Texas USA"},{"name":"Department of Radiology University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baolian","family":"Yang","sequence":"additional","affiliation":[{"name":"MR Cleveland Advanced Diagnostic Imaging Philips Healthcare Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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