{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:23:49Z","timestamp":1790551429862,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T00:00:00Z","timestamp":1413417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["R01EB008743-01A2"],"award-info":[{"award-number":["R01EB008743-01A2"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2015,10]]},"abstract":"\n Purpose<\/jats:title>\n \n To develop a novel MR sequence for combined three\u2010dimensional (3D) phase\u2010sensitive (PS) late gadolinium enhancement (LGE) and T\n 1<\/jats:sub>\n mapping to allow for simultaneous assessment of focal and diffuse myocardial fibrosis.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In the proposed sequence, four 3D imaging volumes are acquired with different T\n 1<\/jats:sub>\n weightings using a combined saturation and inversion preparation, after administration of a gadolinium contrast agent. One image is acquired fully sampled with the inversion time selected to null the healthy myocardial signal (the LGE image). The other three images are three\u2010fold under\u2010sampled and reconstructed using compressed sensing. An acquisition scheme with two interleaved imaging cycles and joint navigator\u2010gating of those cycles ensures spatial registration of the imaging volumes. T\n 1<\/jats:sub>\n maps are generated using all four imaging volumes. The signal\u2010polarity in the LGE image is restored using supplementary information from the T\n 1<\/jats:sub>\n fit to generate PS\u2010LGE images. The accuracy of the proposed method was assessed with respect to a inversion\u2010recovery spin\u2010echo sequence. In vivo T\n 1<\/jats:sub>\n maps and LGE images were acquired with the proposed sequence and quantitatively compared with 2D multislice Modified Look\u2010Locker inversion recovery (MOLLI) T\n 1<\/jats:sub>\n maps. Exemplary images in a patient with focal scar were compared with conventional LGE imaging.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The deviation of the proposed method and the spin\u2010echo reference was\u2009<\u200911 ms in phantom for T\n 1<\/jats:sub>\n times between 250 and 600 ms, regardless of the inversion time selected in the LGE image. There was no significant difference in the in vivo T\n 1<\/jats:sub>\n times of the proposed sequence and the 2D MOLLI technique (myocardium: 292\u2009\u00b1\u200975 ms versus 310\u2009\u00b1\u200949 ms, blood\u2010pools: 191\u2009\u00b1\u200975 ms versus 182.0\u2009\u00b1\u200933). The LGE images showed proper nulling of the healthy myocardium in all subjects and clear depiction of scar in the patient.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The proposed sequence enables simultaneous acquisition of 3D PS\u2010LGE images and spatially registered 3D T\n 1<\/jats:sub>\n maps in a single scan. Magn Reson Med 74:1032\u20131041, 2015. \u00a9 2014 Wiley Periodicals, Inc.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mrm.25495","type":"journal-article","created":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T13:56:43Z","timestamp":1413467803000},"page":"1032-1041","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Free\u2010breathing combined three\u2010dimensional phase sensitive late gadolinium enhancement and T\n 1<\/sub>\n mapping for myocardial tissue characterization"],"prefix":"10.1002","volume":"74","author":[{"given":"Sebastian","family":"Weing\u00e4rtner","sequence":"first","affiliation":[{"name":"Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston Massachusetts USA"},{"name":"Computer Assisted Clinical Medicine University Medical Center Mannheim, Heidelberg University Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Ak\u00e7akaya","sequence":"additional","affiliation":[{"name":"Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Roujol","sequence":"additional","affiliation":[{"name":"Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamer","family":"Basha","sequence":"additional","affiliation":[{"name":"Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory","family":"Tschabrunn","sequence":"additional","affiliation":[{"name":"Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elad","family":"Anter","sequence":"additional","affiliation":[{"name":"Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Nezafat","sequence":"additional","affiliation":[{"name":"Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.19.1992"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011163432003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.218.1.r01ja50215"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1684482"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10051"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1081\/JCMR-120022267"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03567-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000142045.22628.74"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/RMR.0b013e31816fcb22"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.4222"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2003.08.009"},{"key":"e_1_2_7_13_1","first-page":"176","article-title":"Magnetic resonance imaging of myocardial fibrosis in hypertrophic cardiomyopathy","volume":"29","author":"Wilson JM","year":"2002","journal-title":"Tex Heart I J"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.180.4.1800981"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-12-1378"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-12-30"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-15-12"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2008.09.010"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.03.007"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.613414"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.653568"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-15-31"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20110"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.06.049"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21272"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24761"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24242"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21391"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21236"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24385"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23153"},{"key":"e_1_2_7_32_1","unstructured":"StehningC NezafatR GharibAM DesaiMY WeissRG PettigrewRI McVeighER StuberM. Dual navigators for time\u2010resolved MR coronary blood flow imaging at 3T during free breathing. In Proceedings of the 13th Annual Meeting of ISMRM Miami Beach Florida USA 2005. Abstract 1616."},{"key":"e_1_2_7_33_1","unstructured":"PetersDC NezafatR StehningC EggersH ManningWJ. 2D cardiac function during free\u2010breathing with navigators. In Proceedings of the Joint Annual Meeting of ISMRM\u2010ESMRMB Berlin Germany 2007. Abstract 3860."},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22841"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12112489"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-16-2"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24248"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2342-10-19"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25285"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24878"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-12-69"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.1921668"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.25495","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.25495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T17:44:42Z","timestamp":1696527882000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.25495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,16]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1002\/mrm.25495"],"URL":"https:\/\/doi.org\/10.1002\/mrm.25495","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,16]]},"assertion":[{"value":"2014-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-09-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}