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Respiratory motion was corrected with a navigator\u2010guided motion correction framework at near perfect efficiency. Image intensities were fit to a monoexponential function to derive myocardial T<jats:sub>2<\/jats:sub> maps. The proposed 3D, free breathing, motion\u2010corrected (3D\u2010FB\u2010MoCo) approach was studied in ex vivo canine hearts and kidneys, healthy volunteers, and canine subjects with acute myocardial infarction (AMI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ex vivo T<jats:sub>2<\/jats:sub> values from proposed 3D T<jats:sub>2<\/jats:sub>\u2010prep gradient echo were not different from two\u2010dimensional (2D) spin echo (<jats:italic>P<\/jats:italic>\u2009=\u20090.7) and T<jats:sub>2<\/jats:sub>\u2010prep balanced steady\u2010state free precession (bSSFP) (<jats:italic>P<\/jats:italic>\u2009=\u20090.7). In healthy volunteers, compared with 3D\u2010FB\u2010MoCo and breath\u2010held 2D T<jats:sub>2<\/jats:sub>\u2010prep bSSFP (2D\u2010BH), non\u2013motion\u2010corrected (3D\u2010FB\u2010Non\u2010MoCo) myocardial T<jats:sub>2<\/jats:sub> was longer, had a larger coefficient of variation (COV), and had a lower image quality (IQ) score (T<jats:sub>2<\/jats:sub>\u2009=\u200940.3 ms, COV\u2009=\u200938%, and IQ\u2009=\u20092.3; all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Conversely, the mean and COV and IQ of 3D\u2010FB\u2010MoCo (T<jats:sub>2<\/jats:sub>\u2009=\u200937.7 ms, COV\u2009=\u200917%, and IQ\u2009=\u20093.5) and 2D\u2010BH (T<jats:sub>2<\/jats:sub>\u2009=\u200938.0 ms, COV\u2009=\u200915%, and IQ\u2009=\u20093.8) were not different (<jats:italic>P<\/jats:italic>\u2009=\u20090.99, <jats:italic>P<\/jats:italic>\u2009=\u20090.74, and <jats:italic>P<\/jats:italic>\u2009=\u20090.14, respectively). In AMI, T<jats:sub>2<\/jats:sub> values and edema volumes from 3D\u2010FB\u2010MoCo and 2D\u2010BH were closely correlated (R<jats:sup>2<\/jats:sup>\u2009=\u20090.88 and 0.96, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The proposed whole heart T<jats:sub>2<\/jats:sub> mapping approach can be performed within 5 min with similar accuracy to that of the 2D\u2010BH T<jats:sub>2<\/jats:sub> mapping approach. Magn Reson Med 75:126\u2013136, 2016. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.25576","type":"journal-article","created":{"date-parts":[[2015,3,7]],"date-time":"2015-03-07T05:12:10Z","timestamp":1425705130000},"page":"126-136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Free\u2010breathing, motion\u2010corrected, highly efficient whole heart T<sub>2<\/sub> mapping at 3T with hybrid radial\u2010cartesian trajectory"],"prefix":"10.1002","volume":"75","author":[{"given":"Hsin\u2010Jung","family":"Yang","sequence":"first","affiliation":[{"name":"Biomedical Imaging Research Institute Department of Biomedical Sciences Cedars\u2010Sinai Medical Center Los Angeles California USA"},{"name":"Department of Bioengineering University of California Los Angeles California 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