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A sum of Gaussian distributions is fit to coronal slice\u2010wise intensities to extract six descriptive parameters, and a regression forest is used to map the model space to radii. The model is validated for consistency using tenfold cross\u2010validation and for accuracy using a high resolution (0.4 mm<jats:sup>2<\/jats:sup> reconstructed to 0.15 mm<jats:sup>2<\/jats:sup>) in vivo sequence. We evaluated this model on 6 controls and 6 patients with multiple sclerosis (MS) and a history of optic neuritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In simulation, the model was found to have an explanatory R\u2010squared for both ON and sheath radii greater than 0.95. The accuracy of the method was within the measurement error on the highest possible in vivo resolution. Comparing healthy controls and patients with MS, significant structural differences were found near the ON head and the chiasm, and structural trends agreed with the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is a first demonstration that the ON can be exclusively, quantitatively measured and separated from the surrounding CSF using MRI. 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