{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:48:12Z","timestamp":1790689692829,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T00:00:00Z","timestamp":1452643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To develop and evaluate a rapid three\u2010dimensional (3D) quantitative T<jats:sub>2<\/jats:sub> mapping method for prostate cancer imaging using dual echo steady state (DESS) MRI at 3T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In simulations, DESS\u2010T<jats:sub>2<\/jats:sub> mapping in the presence of T<jats:sub>1<\/jats:sub> and \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm26053-math-0001.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm26053:mrm26053-math-0001\"\/> variations was evaluated. In a phantom and in healthy volunteers (n\u2009=\u20094), 3D DESS\u2010T<jats:sub>2<\/jats:sub> mapping was compared with a two\u2010dimensional turbo spin echo (TSE) approach. In volunteers and a pilot patient study (n\u2009=\u200929), quantitative T<jats:sub>2<\/jats:sub> in normal prostate anatomical zones and in suspected cancerous lesions was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The simulated bias for DESS\u2010T<jats:sub>2<\/jats:sub> was\u2009&lt;\u20092% (5%) for typically observed T<jats:sub>1<\/jats:sub> (\n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm26053-math-0002.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm26053:mrm26053-math-0002\"\/>) variations. In phantoms and in vivo, high correlation of DESS\u2010T<jats:sub>2<\/jats:sub> and TSE\u2010T<jats:sub>2<\/jats:sub> (r<jats:sup>2<\/jats:sup>\u2009=\u20090.98 and 0.88, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) was found. DESS\u2010T<jats:sub>2<\/jats:sub> in the normal peripheral zone and transition zone was 115\u2009\u00b1\u200926 ms and 64\u2009\u00b1\u20097 ms, respectively, in healthy volunteers and 129\u2009\u00b1\u200939 ms and 83\u2009\u00b1\u200912 ms, respectively, in patients. In suspected cancerous lesions, DESS\u2010T<jats:sub>2<\/jats:sub> was 72\u2009\u00b1\u200914 ms, which was significantly decreased from the normal peripheral zone (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) but not from the transition zone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rapid 3D T<jats:sub>2<\/jats:sub> mapping in the entire prostate can be performed in 1\u2009min using DESS MRI. Magn Reson Med 76:1720\u20131729, 2016. \u00a9 2016 International Society for Magnetic Resonance in Medicine<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.26053","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T08:57:37Z","timestamp":1452761857000},"page":"1720-1729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Rapid quantitative T<sub>2<\/sub> mapping of the prostate using three\u2010dimensional dual echo steady state MRI at 3T"],"prefix":"10.1002","volume":"76","author":[{"given":"Isabel","family":"Dregely","sequence":"first","affiliation":[{"name":"Department of Radiological Sciences University of California Los Angeles California USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A. 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