{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:32:33Z","timestamp":1790094753513,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T00:00:00Z","timestamp":1455753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FP7\u2010PEOPLE\u20102012\u2010ITN\u2010316716"],"award-info":[{"award-number":["FP7\u2010PEOPLE\u20102012\u2010ITN\u2010316716"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To optimize intracranial vessel wall imaging (VWI) at 7T for sharp wall depiction and high boundary contrast.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A variable flip angle turbo spin echo scheme (SPACE) was optimized for VWI. SPACE provides black\u2010blood contrast, but has less crushing effect on cerebrospinal fluid (CSF). However, a delay alternating with nutation for tailored excitation (DANTE) preparation suppresses the signal from slowly moving spins of a few mm per second. Therefore, we optimized a DANTE\u2010preparation module for 7T. Signal\u2010to\u2010noise ratio (SNR), contrast\u2010to\u2010noise ratio (CNR), and signal ratio for vessel wall, CSF, and lumen were calculated for SPACE and DANTE\u2010SPACE in 11 volunteers at the middle cerebral artery (MCA). An exemplar MCA stenosis patient was scanned with DANTE\u2010SPACE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 7T\u2010optimized SPACE sequence improved the vessel wall point\u2010spread function by 17%. The CNR between the wall and CSF was doubled (12.2 versus 5.6) for the DANTE\u2010SPACE scans compared with the unprepared SPACE. This increase was significant in the right hemisphere (<jats:italic>P<\/jats:italic>\u2009=\u20090.016), but not in the left (<jats:italic>P<\/jats:italic>\u2009=\u20090.090). The CNR between wall and lumen was halved, but remained at a high value (24.9 versus 56.5).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The optimized SPACE sequence improves VWI at 7T. Additional DANTE preparation increases the contrast between the wall and CSF. Increased outer boundary contrast comes at the cost of reduced inner boundary contrast. Magn Reson Med 77:655\u2013663, 2017. \u00a9 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.26152","type":"journal-article","created":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T22:23:17Z","timestamp":1455834197000},"page":"655-663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["T2\u2010Weighted intracranial vessel wall imaging at 7 Tesla using a <scp>DANTE<\/scp>\u2010prepared variable flip angle turbo spin echo readout (<scp>DANTE\u2010SPACE<\/scp>)"],"prefix":"10.1002","volume":"77","author":[{"given":"Olivia","family":"Viessmann","sequence":"first","affiliation":[{"name":"FMRIB Centre, Nuffield Department of Clinical Neurosciences John Radcliffe Hospital Oxford OX3 9DU UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linqing","family":"Li","sequence":"additional","affiliation":[{"name":"FMRIB Centre, Nuffield Department of Clinical Neurosciences John Radcliffe Hospital Oxford OX3 9DU UK"},{"name":"Molecular Imaging Branch, National Institute of Mental Health National Institutes of Health Bethesda Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Neurosciences Research Centre, St George's Hospital University of London  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Jezzard","sequence":"additional","affiliation":[{"name":"FMRIB Centre, Nuffield Department of Clinical Neurosciences John Radcliffe Hospital Oxford OX3 9DU UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00685305"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2012.00575.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20863"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24542"},{"key":"e_1_2_7_6_1","article-title":"Whole\u2010brain FLAIR using 3D TSE with variable flip angle readouts optimized for 7 Tesla","author":"Grinstead JW","journal-title":"In Proceedings of the 18th Annual Meeting of ISMRM, Stockholm, Sweden, 2010. 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