{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T22:13:39Z","timestamp":1768083219946,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T00:00:00Z","timestamp":1456185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Separate measurements are required when investigating multiple exercising muscles with singlevoxel\u2010localized dynamic <jats:sup>31<\/jats:sup>P\u2010MRS. With multivoxel spectroscopy, <jats:sup>31<\/jats:sup>P\u2010MRS time\u2010series spectra are acquired from multiple independent regions during one exercise\u2010recovery experiment with the same time resolution as for singlevoxel measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multiple independently selected volumes were localized using temporally interleaved semi\u2010LASER excitations at 7T. Signal loss caused by mutual saturation from shared excitation or refocusing slices was quantified at partial and full overlap, and potential contamination was investigated in phantom measurements. During an exercise\u2010recovery experiment both gastrocnemius medialis and soleus of two healthy volunteers were measured using multivoxel acquisitions with a total <jats:italic>T<\/jats:italic><jats:sub>R<\/jats:sub> of 6 s, while avoiding overlap of excitation slices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Signal reduction by shared adiabatic refocusing slices selected 1 s after the preceding voxel was between 10% (full overlap) and 20% (half overlap), in a phantom measurement. In vivo data were acquired from both muscles within the same exercise experiment, with 13\u201318% signal reduction. Spectra show phosphocreatine, inorganic phosphate, adenosine\u2010triposphate, phosphomonoesters, and phosphodiesters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Signal decrease was relatively low compared to the 2\u2010fold increase in information. The approach could help to improve the understanding in metabolic research and is applicable to other organs and nuclei. Magn Reson Med 77:921\u2013927, 2017. \u00a9 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/creativecommons.org\/licenses\/by\/4.0\/\">Creative Commons Attribution<\/jats:ext-link> License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.26172","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T01:53:50Z","timestamp":1456451630000},"page":"921-927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Interleaved multivoxel <sup>31<\/sup>P MR spectroscopy"],"prefix":"10.1002","volume":"77","author":[{"given":"Fabian","family":"Niess","sequence":"first","affiliation":[{"name":"Center for Medical Physics and Biomedical Engineering Medical University of Vienna, Vienna  Austria"},{"name":"MR Center of Excellence, Medical University of Vienna Vienna Austria"},{"name":"Faculty of Physics Technical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg B.","family":"Fiedler","sequence":"additional","affiliation":[{"name":"Center for Medical Physics and Biomedical Engineering Medical University of Vienna, Vienna  Austria"},{"name":"MR Center of Excellence, Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albrecht I.","family":"Schmid","sequence":"additional","affiliation":[{"name":"Center for Medical Physics and Biomedical Engineering Medical University of Vienna, Vienna  Austria"},{"name":"MR Center of Excellence, Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigrun","family":"Goluch","sequence":"additional","affiliation":[{"name":"Center for Medical Physics and Biomedical Engineering Medical University of Vienna, Vienna  Austria"},{"name":"MR Center of Excellence, Medical University of Vienna Vienna Austria"},{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine III Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Kriegl","sequence":"additional","affiliation":[{"name":"Center for Medical Physics and Biomedical Engineering Medical University of Vienna, Vienna  Austria"},{"name":"MR Center of Excellence, Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Wolzt","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewald","family":"Moser","sequence":"additional","affiliation":[{"name":"Center for Medical Physics and Biomedical Engineering Medical University of Vienna, Vienna  Austria"},{"name":"MR Center of Excellence, Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Meyerspeer","sequence":"additional","affiliation":[{"name":"Center for Medical Physics and Biomedical Engineering Medical University of Vienna, Vienna  Austria"},{"name":"MR Center of Excellence, Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/252285a0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1109"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1192"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1794"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24205"},{"key":"e_1_2_7_7_1","first-page":"1190","article-title":"A form\u2010fitted three channel 31P, two channel 1H transceiver coil array for calf muscle studies at 7T","volume":"73","author":"Goluch S","year":"2014","journal-title":"Magn Reson Med"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22057"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(87)90328-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3196"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22730"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-015-0484-5"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1413"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24456"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25822"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-007-0094-y"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910200104"},{"key":"e_1_2_7_18_1","unstructured":"BottomleyPA.Selective volume method for performing localized NMR spectroscopy. U.S. Patent 4 480 228 1984."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(87)90154-5"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25718"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.1997.1244"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02668096"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-005-0014-y"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.2952"},{"key":"e_1_2_7_25_1","first-page":"283","article-title":"Image\u2010selected in vivo spectroscopy (ISIS). A new technique for spatially selective NMR spectroscopy","volume":"38","author":"Ordidge R","year":"1986","journal-title":"JMR"},{"key":"e_1_2_7_26_1","first-page":"508","volume-title":"In vivo NMR spectroscopy","author":"Graaf RA.","year":"1998"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200010)44:4<546::AID-MRM8>3.0.CO;2-7"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.26172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.26172","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.26172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:01:29Z","timestamp":1696330889000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.26172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,23]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1002\/mrm.26172"],"URL":"https:\/\/doi.org\/10.1002\/mrm.26172","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,23]]},"assertion":[{"value":"2015-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}