{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:50:15Z","timestamp":1790635815801,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T00:00:00Z","timestamp":1456272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010AR050068"],"award-info":[{"award-number":["R01\u2010AR050068"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010AG038693"],"award-info":[{"award-number":["R01\u2010AG038693"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21\u2010NS082953"],"award-info":[{"award-number":["R21\u2010NS082953"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To design and evaluate an optimized PETRA (point\u2010wise encoding time reduction with radial acquisition) sequence with long\u2010<jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> suppression at 3 Tesla.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An adiabatic inversion recovery\u2010based scheme was used to null the long\u2010<jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> signal. To minimize scan time, the signal was sampled multiple times after each inversion with variable excitation flip angles designed to yield constant short\u2010<jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> signal amplitude. The excitation pulses were phase\u2010modulated, allowing for increased flip angle and higher signal\u2010to\u2010noise ratio (SNR). A fast, noniterative image reconstruction algorithm was designed to minimize image artifacts due to nonuniform excitation profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Phase\u2010modulated pulse excitation, along with the noniterative reconstruction algorithm, allows the use of larger radiofrequency pulse flip angles, resulting in effective suppression of long\u2010<jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> protons and improved image SNR without causing image artifacts. Midtibia images representative of collagen\u2010bound water yielded SNR of 15 at 1\u2010mm isotropic resolution in 6.5 minutes with a standard extremity coil. Further, the technology is shown to be suited for generating multi\u2010angle projection images of bone akin to X\u2010ray images displaying subtle anatomic detail.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Optimized long\u2010<jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> suppressed PETRA allows imaging of bone matrix water unencumbered by long\u2010<jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> soft tissue and pore water protons, opening up new possibilities for anatomic bone imaging at isotropic resolution and quantification in clinically practical scan times. Magn Reson Med 77:989\u2013997, 2017. \u00a9 2016 International Society for Magnetic Resonance in Medicine<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.26178","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T03:33:24Z","timestamp":1456457604000},"page":"989-997","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Selective in vivo bone imaging with long\u2010<i>T<\/i><sub>2<\/sub> suppressed PETRA MRI"],"prefix":"10.1002","volume":"77","author":[{"given":"Cheng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiology University of Pennsylvania Philadelphia Pennsylvania USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy F.","family":"Magland","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pennsylvania Philadelphia Pennsylvania USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pennsylvania Philadelphia Pennsylvania USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan C.","family":"Seifert","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pennsylvania Philadelphia Pennsylvania USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix W.","family":"Wehrli","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pennsylvania Philadelphia Pennsylvania USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115107109"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1631"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.179.3.2027991"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.2930"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-03078-3"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-200311000-00001"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21174"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22799"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23017"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2006.05.014"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23267"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2010.11.003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24186"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14132585"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1535"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24870"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23047"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3246"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2011.10.005"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2014.2300500"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910010308"},{"key":"e_1_2_8_23_1","unstructured":"LiC MaglandJF SeifertAC WehrliFW.A fast algorithm to correct excitation profile in zero echo time (ZTE) imaging. 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