{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T08:56:47Z","timestamp":1784105807648,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T00:00:00Z","timestamp":1457308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To develop a model\u2010based reconstruction technique for real\u2010time phase\u2010contrast flow MRI with improved spatiotemporal accuracy in comparison to methods using phase differences of two separately reconstructed images with differential flow encodings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The proposed method jointly computes a common image, a phase\u2010contrast map, and a set of coil sensitivities from every pair of flow\u2010compensated and flow\u2010encoded datasets obtained by highly undersampled radial FLASH. Real\u2010time acquisitions with five and seven radial spokes per image resulted in 25.6 and 35.7 ms measuring time per phase\u2010contrast map, respectively. The signal model for phase\u2010contrast flow MRI requires the solution of a nonlinear inverse problem, which is accomplished by an iteratively regularized Gauss\u2010Newton method. Aspects of regularization and scaling are discussed. The model\u2010based reconstruction was validated for a numerical and experimental flow phantom and applied to real\u2010time phase\u2010contrast MRI of the human aorta for 10 healthy subjects and 2 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Under all conditions, and compared with a previously developed real\u2010time flow MRI method, the proposed method yields quantitatively accurate phase\u2010contrast maps (i.e., flow velocities) with improved spatial acuity, reduced phase noise and reduced streaking artifacts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This novel model\u2010based reconstruction technique may become a new tool for clinical flow MRI in real time. Magn Reson Med 77:1082\u20131093, 2017. \u00a9 2016 International Society for Magnetic Resonance in Medicine<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.26192","type":"journal-article","created":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T13:07:38Z","timestamp":1457356058000},"page":"1082-1093","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Model\u2010based reconstruction for real\u2010time phase\u2010contrast flow MRI: Improved spatiotemporal accuracy"],"prefix":"10.1002","volume":"77","author":[{"given":"Zhengguo","family":"Tan","sequence":"first","affiliation":[{"name":"Biomedizinische NMR Forschungs GmbH am Max\u2010Planck\u2010Institut f\u00fcr biophysikalische Chemie G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkert","family":"Roeloffs","sequence":"additional","affiliation":[{"name":"Biomedizinische NMR Forschungs GmbH am Max\u2010Planck\u2010Institut f\u00fcr biophysikalische Chemie G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Voit","sequence":"additional","affiliation":[{"name":"Biomedizinische NMR Forschungs GmbH am Max\u2010Planck\u2010Institut f\u00fcr biophysikalische Chemie G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun A.","family":"Joseph","sequence":"additional","affiliation":[{"name":"Biomedizinische NMR Forschungs GmbH am Max\u2010Planck\u2010Institut f\u00fcr biophysikalische Chemie G\u00f6ttingen Germany"},{"name":"DZHK, German Center for Cardiovascular Research, partner site G\u00f6ttingen  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Untenberger","sequence":"additional","affiliation":[{"name":"Biomedizinische NMR Forschungs GmbH am Max\u2010Planck\u2010Institut f\u00fcr biophysikalische Chemie G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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