{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:22:03Z","timestamp":1790882523044,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T00:00:00Z","timestamp":1469404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institute of Health (NIH)","award":["R21AR066897, RO1AR067789"],"award-info":[{"award-number":["R21AR066897, RO1AR067789"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>We establish a mechanical injury model for articular cartilage to assess the sensitivity of diffusion tensor imaging (DTI) in detecting cartilage damage early in time. Mechanical injury provides a more realistic model of cartilage degradation compared with commonly used enzymatic degradation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine cartilage\u2010on\u2010bone samples were obtained from patients undergoing knee replacement. The 3 Tesla DTI (0.18\u2009\u00d7\u20090.18\u2009\u00d7\u20091\u2009mm<jats:sup>3<\/jats:sup>) was performed before, 1 week, and 2 weeks after (zero, mild, and severe) injury, with a clinical radial spin\u2010echo DTI (RAISED) sequence used in our hospital. We performed stress\u2010relaxation tests and used a quasilinear\u2010viscoelastic (QLV) model to characterize cartilage mechanical properties. Serial histology sections were dyed with Safranin\u2010O and given an OARSI grade. We then correlated the changes in DTI parameters with the changes in QLV\u2010parameters and OARSI grades.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After severe injury the mean diffusivity increased after 1 and 2 weeks, whereas the fractional anisotropy decreased after 2 weeks (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The QLV\u2010parameters and OARSI grades of the severe injury group differed from the baseline with statistical significance. The changes in mean diffusivity across all the samples correlated with the changes in the OARSI grade (r\u2009=\u20090.72) and QLV\u2010parameters (r\u2009=\u2009\u22120.75).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DTI is sensitive in tracking early changes after mechanical injury, and its changes correlate with changes in biomechanics and histology. Magn Reson Med 78:69\u201378, 2017. \u00a9 2016 International Society for Magnetic Resonance in Medicine<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.26336","type":"journal-article","created":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T14:23:45Z","timestamp":1469456625000},"page":"69-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Diffusion tensor imaging of articular cartilage at 3T correlates with histology and biomechanics in a mechanical injury model"],"prefix":"10.1002","volume":"78","author":[{"given":"Uran","family":"Ferizi","sequence":"first","affiliation":[{"name":"Department of Radiology New York University School of Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Radiology New York University School of Medicine New York New York USA"},{"name":"Centro de 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