{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:26:49Z","timestamp":1790483209808,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,12,26]],"date-time":"2016-12-26T00:00:00Z","timestamp":1482710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 MH084021"],"award-info":[{"award-number":["R01 MH084021"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS067015"],"award-info":[{"award-number":["R01 NS067015"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG042753"],"award-info":[{"award-number":["R01 AG042753"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG047972"],"award-info":[{"award-number":["R01 AG047972"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 NS095342"],"award-info":[{"award-number":["R21 NS095342"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 NS085634"],"award-info":[{"award-number":["R21 NS085634"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41 EB015909"],"award-info":[{"award-number":["P41 EB015909"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Assessment of brain hemodynamics without exogenous contrast agents is of increasing importance in clinical applications. This study aims to develop an MR perfusion technique that can provide noncontrast and multiparametric estimation of hemodynamic markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We devised an arterial spin labeling (ASL) method based on the principle of MR fingerprinting (MRF), referred to as MRF\u2010ASL. By taking advantage of the rich information contained in MRF sequence, up to seven hemodynamic parameters can be estimated concomitantly. Feasibility demonstration, flip angle optimization, comparison with Look\u2010Locker ASL, reproducibility test, sensitivity to hypercapnia challenge, and initial clinical application in an intracranial steno\u2010occlusive process, Moyamoya disease, were performed to evaluate this technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Magnetic resonance fingerprinting ASL provided estimation of up to seven parameters, including \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm26587-math-0002.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm26587:mrm26587-math-0002\"\/>, tissue T<jats:sub>1<\/jats:sub>, cerebral blood flow (CBF), tissue bolus arrival time (BAT), pass\u2010through arterial BAT, pass\u2010through blood volume, and pass\u2010through blood travel time. Coefficients of variation of the estimated parameters ranged from 0.2 to 9.6%. Hypercapnia resulted in an increase in CBF by 57.7%, and a decrease in BAT by 13.7 and 24.8% in tissue and vessels, respectively. Patients with Moyamoya disease showed diminished CBF and lengthened BAT that could not be detected with regular ASL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Magnetic resonance fingerprinting ASL is a promising technique for noncontrast, multiparametric perfusion assessment. Magn Reson Med 78:1812\u20131823, 2017. \u00a9 2016 International Society for Magnetic Resonance in Medicine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.26587","type":"journal-article","created":{"date-parts":[[2016,12,26]],"date-time":"2016-12-26T06:09:03Z","timestamp":1482732543000},"page":"1812-1823","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Multiparametric estimation of brain hemodynamics with MR fingerprinting ASL"],"prefix":"10.1002","volume":"78","author":[{"given":"Pan","family":"Su","sequence":"first","affiliation":[{"name":"The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore Maryland USA"},{"name":"Graduate School of Biomedical Sciences University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng","family":"Mao","sequence":"additional","affiliation":[{"name":"The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore Maryland USA"},{"name":"Graduate School of Biomedical Sciences University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiying","family":"Liu","sequence":"additional","affiliation":[{"name":"The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore Maryland USA"},{"name":"Graduate School of Biomedical Sciences University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco C.","family":"Pinho","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babu G.","family":"Welch","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanzhang","family":"Lu","sequence":"additional","affiliation":[{"name":"The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.1.FOCUS08300"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.616466"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70195-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.192616"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.631929"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199907000-00001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfk062"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25197"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2012.02.003"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11971"},{"key":"e_1_2_6_12_1","unstructured":"WrightKL MaD JiangY GulaniV GriswoldMA Hernandez\u2010GarciaL.Theoretical framework for MR fingerprinting with ASL: simultaneous auantification of CBF transit time and T1. In Proceedings of the 22nd Annual Meeting of ISMRM Milan Italy 2014. Abstract 0417."},{"key":"e_1_2_6_13_1","unstructured":"SuP MaoD LiuP LiY WelchBG LuH.Arterial spin labeling without control\/label pairing and post\u2010labeling delay: an MR fingerprinting implementation. In Proceedings of the 23th Annual Meeting of ISMRM Toronto Canada 2015. Abstract 0276."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1985.9"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910400308"},{"key":"e_1_2_6_16_1","volume-title":"MR and CT Perfusion and Pharmacokinetic Imaging: Clinical Applications and Theoretical Principles","author":"Wang DJ","year":"2016"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20178"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1284"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20784"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.07.068"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21790"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1969.00480090076012"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-014-3098-9"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1109\/TSP.2008.2005752"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22320"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(200005)43:5<739::AID-MRM17>3.0.CO;2-2"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22256"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.06.017"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23103"},{"key":"e_1_2_6_31_1","unstructured":"GuntherM.Highly efficient accelerated acquisition of perfusion inflow series by cycled arterial spin labeling. In Proceedings of the 15th Annual Meeting of ISMRM Berlin Germany 2007. Abstract 380."},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22266"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24335"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25083"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10559"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22601"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.08.025"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.126"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.81"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22844"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.208.2.9680569"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25776"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25799"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24260"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.26587","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.26587","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.26587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T13:52:46Z","timestamp":1695045166000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.26587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,26]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1002\/mrm.26587"],"URL":"https:\/\/doi.org\/10.1002\/mrm.26587","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,26]]},"assertion":[{"value":"2016-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}