{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:18:22Z","timestamp":1788185902722,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,5]],"date-time":"2017-02-05T00:00:00Z","timestamp":1486252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Supported by the intramural programs of the NIH and NIMH"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To simultaneously measure concentration and <jats:italic>T<\/jats:italic><jats:sub><jats:italic>1<\/jats:italic><\/jats:sub> and <jats:italic>T<\/jats:italic><jats:sub><jats:italic>2<\/jats:italic><\/jats:sub> values of metabolites in the human brain in a single scan session.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A new pulse sequence with multiple variable acquisition parameters was proposed to encode metabolite <jats:italic>T<\/jats:italic><jats:sub><jats:italic>1<\/jats:italic><\/jats:sub> and <jats:italic>T<\/jats:italic><jats:sub><jats:italic>2<\/jats:italic><\/jats:sub> information into the acquired data. A linear combination\u2010fitting algorithm was developed in\u2010house to simultaneously determine metabolite concentrations and relaxation times.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Concentration, <jats:italic>T<\/jats:italic><jats:sub><jats:italic>1<\/jats:italic><\/jats:sub>, and <jats:italic>T<\/jats:italic><jats:sub><jats:italic>2<\/jats:italic><\/jats:sub> values of N\u2010acetyl\u2010aspartate, total creatine, total choline, and glutamate were reliably measured in the frontal gray matter and white matter regions of nine healthy volunteers at 7 tesla in less than 10 minutes of scan time per voxel. <jats:italic>T<\/jats:italic><jats:sub><jats:italic>1<\/jats:italic><\/jats:sub> and <jats:italic>T<\/jats:italic><jats:sub><jats:italic>2<\/jats:italic><\/jats:sub> values of glutamine, as well as <jats:italic>T<\/jats:italic><jats:sub><jats:italic>1<\/jats:italic><\/jats:sub> of glutathione, were also measured in the frontal gray matter region with reasonable precision.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The proposed technique allows multiparametric characterization of brain metabolites in a single scan session, making it possible to measure both levels and intracellular microenvironments of brain chemicals in clinical MR spectroscopy studies. 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