{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:38:42Z","timestamp":1760985522609,"version":"3.37.3"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T00:00:00Z","timestamp":1487116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["MOP 106437"],"award-info":[{"award-number":["MOP 106437"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Canadian Respiratory Research Network"},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001448","name":"Alpha-1 Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001448","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>We generated lung morphometry measurements using single\u2010breath diffusion\u2010weighted MRI and three different acinar duct models in healthy participants and patients with emphysema stemming from chronic obstructive lung disease (COPD) and alpha\u20101 antitrypsin deficiency (AATD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Single\u2010breath\u2010inhaled <jats:sup>3<\/jats:sup>He MRI with five diffusion sensitizations (b\u2010value\u2009=\u20090, 1.6, 3.2, 4.8, and 6.4 s\/cm<jats:sup>2<\/jats:sup>) was used, and signal intensities were fit using a cylindrical and single\u2010compartment acinar\u2010duct model to estimate MRI\u2010derived mean linear intercept (<jats:italic>L<\/jats:italic><jats:sub>m<\/jats:sub>) and surface\u2010to\u2010volume ratio (<jats:italic>S\/V<\/jats:italic>). A stretched exponential model was also developed to estimate the mean airway length and <jats:italic>L<\/jats:italic><jats:sub>m<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We evaluated 42 participants, including 15 elderly never\u2010smokers (69\u2009\u00b1\u20095 years), 12 ex\u2010smokers without COPD (67\u2009\u00b1\u200911 years), 9 COPD ex\u2010smokers (80\u2009\u00b1\u20096 years), and 6 AATD patients (59\u2009\u00b1\u20096 years). In the never\u2010 and ex\u2010smokers, the diffusing capacity of the lung for carbon monoxide (DL<jats:sub>CO<\/jats:sub>) and computed tomography relative area of less than <jats:italic>\u2212<\/jats:italic>950 Hounsfield units (RA<jats:sub>950<\/jats:sub>) were normal, but these were abnormal in the COPD and AATD patients, which is reflective of emphysema. Although cylindrical and stretched\u2010exponential\u2010model estimates of <jats:italic>L<\/jats:italic><jats:sub>m<\/jats:sub> and <jats:italic>S\/V<\/jats:italic> were not significantly different, the single\u2010compartment\u2010model estimates were significantly different (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) for the never\u2010 and ex\u2010smoker subgroups. All models estimated significantly worse <jats:italic>L<\/jats:italic><jats:sub>m<\/jats:sub> and <jats:italic>S\/V<\/jats:italic> in the AATD and COPD subgroups compared with the never\u2010 and ex\u2010smokers without emphysema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Differences in airspace enlargement may be estimated using <jats:italic>L<\/jats:italic><jats:sub>m<\/jats:sub> and <jats:italic>S<\/jats:italic>\/<jats:italic>V<\/jats:italic>, generated using MRI and a stretched\u2010exponential or cylindrical model of the acinar ducts. Magn Reson Med 79:439\u2013448, 2018. \u00a9 2017 International Society for Magnetic Resonance in Medicine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.26642","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T13:12:43Z","timestamp":1487164363000},"page":"439-448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Pulmonary MRI morphometry modeling of airspace enlargement in chronic obstructive pulmonary disease and alpha\u20101 antitrypsin deficiency"],"prefix":"10.1002","volume":"79","author":[{"given":"Alexei","family":"Ouriadov","sequence":"first","affiliation":[{"name":"Robarts Research Institute London Canada"},{"name":"Department of Medical Biophysics the University of Western Ontario London Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Lessard","sequence":"additional","affiliation":[{"name":"Robarts Research Institute London Canada"},{"name":"Department of Medical Biophysics the University of Western Ontario London Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadija","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Robarts Research Institute London Canada"},{"name":"Department of Medical Biophysics the University of Western Ontario London Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Parraga","sequence":"additional","affiliation":[{"name":"Robarts Research Institute London Canada"},{"name":"Department of Medical Biophysics the University of Western Ontario London Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Canadian Respiratory Research Network","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200008)44:2<174::AID-MRM2>3.0.CO;2-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21076"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2307\/2313748"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199910)42:4<721::AID-MRM14>3.0.CO;2-D"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23056"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2221001834"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201108-1428CI"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2010.02.023"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2012.10.008"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2004.12.011"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20213"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092200410"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2007.10.015"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-803675-4.00012-9"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052594699"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00386.2009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00429.2012"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25825"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22737"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25408"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24595"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203983"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e318262292e"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/scrt95"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevB.47.8565"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.83.3324"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20632"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2007.903192"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26120"},{"key":"e_1_2_7_31_1","unstructured":"Parra\u2010RoblesJ MarshallH WildJM.Characterization of 3He diffusion in lungs using a stretched exponential model [abstract]. 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