{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:08:51Z","timestamp":1787170131812,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T00:00:00Z","timestamp":1490918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The first part of the experiment identifies and validates MRI biomarkers distinctive of the disease progression in the transgenic superoxide dismutase gene (SOD1(G93A)) animal model. The second part assesses the efficacy of a mesenchymal stem cell\u2010based therapy through the MRI biomarkers previously defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The first part identifies MRI differences between SOD1(G93A) and healthy mice. The second part of the experiment follows the disease evolution of stem cell\u2010treated and non\u2013stem\u2010cell treated SOD1(G93A) mice. The analysis focused on voxel\u2010based morphometry and T2 mapping on the brain tissues, and T2\u2010weighted imaging and diffusion tensor imaging (DTI) on the hind limbs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Comparing diseased mice to healthy control revealed gray matter alterations in the brainstem area, accompanied by increased T2 relaxation time. Differences in muscle volume, muscle signal intensity, fractional anisotropy, axial diffusivity, and radial diffusivity were measured in the hind limbs. In the comparison between stem cell\u2010treated mice and nontreated ones, differences in muscle volume, muscle signal intensity, and DTI\u2010derived maps were found.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MRI\u2010derived biomarkers can be used to identify differences between stem cell\u2010treated and nontreated SOD1(G93A) mice. Magn Reson Med 79:459\u2013469, 2018. \u00a9 2017 International Society for Magnetic Resonance in Medicine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.26685","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T12:23:47Z","timestamp":1490963027000},"page":"459-469","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["MRI reveals therapeutical efficacy of stem cells: An experimental study on the SOD1(G93A) animal model"],"prefix":"10.1002","volume":"79","author":[{"given":"Pietro","family":"Bontempi","sequence":"first","affiliation":[{"name":"Department of Computer Science University of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Busato","sequence":"additional","affiliation":[{"name":"Department of Computer Science University of Verona Verona 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