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Time delays inserted after preparation pulses and T<jats:sub>2<\/jats:sub>\u2010magnetization\u2010prep duration are used to adjust tissue contrast. Selection of these parameters was optimized using numerical simulations and phantom experiments. We evaluated DB\u2010LGE in 9 swine and 42 patients (56 \u00b1 14 years, 33 male). Improvement in scar\u2013blood contrast and overall image quality was subjectively evaluated by two independent readers (1 = poor, 4 = excellent). The signal ratios among scar, blood, and myocardium were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Simulations and phantom studies demonstrated that simultaneous nulling of myocardium and blood can be achieved by selecting appropriate timing parameters. The scar\u2013blood contrast score was significantly higher for DB\u2010LGE (<jats:italic>P<\/jats:italic> &lt; 0.001) with no significant difference in overall image quality (<jats:italic>P<\/jats:italic> &gt; 0.05). Scar\u2013blood signal ratios for DB\u2010LGE versus LGE were 5.0 \u00b1 2.8 versus 1.5 \u00b1 0.5 (<jats:italic>P<\/jats:italic> &lt; 0.001) for patients, and 2.2 \u00b1 0.7 versus 1.0 \u00b1 0.4 (<jats:italic>P<\/jats:italic> = 0.0023) for animals. Scar\u2013myocardium signal ratios were 5.7 \u00b1 2.9 versus 6.3 \u00b1 2.6 (<jats:italic>P<\/jats:italic> = 0.35) for patients, and 3.7 \u00b1 1.1 versus 4.1 \u00b1 2.0 (<jats:italic>P<\/jats:italic> = 0.60) for swine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The DB\u2010LGE sequence simultaneously reduces normal myocardium and blood signal intensity, thereby enhancing scar\u2013blood contrast while preserving scar\u2013myocardium contrast. Magn Reson Med 79:351\u2013360, 2018. \u00a9 2017 International Society for Magnetic Resonance in Medicine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.26692","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T04:54:44Z","timestamp":1491454484000},"page":"351-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Improved dark blood late gadolinium enhancement (DB\u2010LGE) imaging using an optimized joint inversion preparation and T<sub>2<\/sub> magnetization preparation"],"prefix":"10.1002","volume":"79","author":[{"given":"Tamer A.","family":"Basha","sequence":"first","affiliation":[{"name":"Department of Medicine (Cardiovascular Division) Beth Israel Deaconess Medical Center and Harvard Medical School Boston Massachusetts USA"},{"name":"Biomedical Engineering Department Cairo University Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxine 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