{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:54:17Z","timestamp":1778979257637,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T00:00:00Z","timestamp":1491782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Reduced bone strength is associated with a loss of bone mass, usually evaluated by dual\u2010energy X\u2010ray absorptiometry, although it is known that the bone microstructure also affects the bone strength. Here, a method is proposed to measure (in laboratory) the bone volume\u2013to\u2013total volume ratio by single\u2010sided NMR scanners, which is related to the microstructure of the trabecular bone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three single\u2010sided scanners were used on animal bone samples. These low\u2010field, mobile, low\u2010cost devices are able to detect the NMR signal, regardless of the sample sizes, without the use of ionizing radiations, with the further advantage of signal localization offered by their intrinsic magnetic field gradients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The performance of the different single\u2010sided scanners have been discussed. The results have been compared with bone volume\u2013to\u2013total volume ratio by micro CT and MRI, obtaining consistent values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results demonstrate the feasibility of the method for laboratory analyses, which are useful for measurements like porosity on bone specimens. This can be considered as the first step to develop an NMR method based on the use of a mobile single\u2010sided device, for the diagnosis of osteoporosis, through the acquisition of the signal from the appendicular skeleton, allowing for low\u2010cost, wide screening campaigns. Magn Reson Med 79:501\u2013510, 2018. \u00a9 2017 International Society for Magnetic Resonance in Medicine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.26697","type":"journal-article","created":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T10:09:02Z","timestamp":1491818942000},"page":"501-510","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Bone volume\u2013to\u2013total volume ratio measured in trabecular bone by single\u2010sided NMR devices"],"prefix":"10.1002","volume":"79","author":[{"given":"Leonardo","family":"Brizi","sequence":"first","affiliation":[{"name":"Department of Physics and Astronomy University of Bologna  Bologna, Italy"},{"name":"Centro Fermi \u2010 Museo Storico della Fisica e Centro Studi e Ricerche \u201cEnrico Fermi\u201d Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Barbieri","sequence":"additional","affiliation":[{"name":"Department of 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