{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:46:47Z","timestamp":1790714807803,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:00:00Z","timestamp":1496707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"German Federal Ministry of Education and Research","award":["LiSyM 031L0057"],"award-info":[{"award-number":["LiSyM 031L0057"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To demonstrate the feasibility of in vivo multifrequency magnetic resonance elastography (MRE) of the prostate using externally placed drivers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three pressurized\u2010air drivers were used to excite shear waves within the prostate at vibration frequencies of 60, 70, and 80\u2009Hz. Full 3D wave fields were acquired by multislice spin\u2010echo echo\u2010planar imaging in conjunction with tomoelastography wave speed recovery for generating full field\u2010of\u2010view stiffness maps. Twelve healthy volunteers were repeatedly scanned to analyze test\u2013retest reproducibility. Five patients with suspected prostate cancer were investigated to demonstrate the clinical feasibility of the method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In healthy volunteers, the shear wave speed of the entire prostate was 2.24\u2009\u00b1\u20090.20\u2009m\/s with a repeatability coefficient of 0.14\u2009m\/s and 88% intraclass correlation coefficient. No significant difference between the peripheral zone (2.27\u2009\u00b1\u20090.20\u2009m\/s) and the central gland (2.22\u2009\u00b1\u20090.23\u2009m\/s) was observed. In patients, wave\u2010speed maps displayed stiff regions consistent with the localization of suspicious masses detected by other imaging markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The proposed method provides reproducible quantitative maps of tissue stiffness throughout the pelvic region and can easily be integrated into clinical imaging protocols. Clinical stiffness maps display many details of potential interest for cancer diagnosis. Magn Reson Med 79:1325\u20131333, 2018. \u00a9 2017 International Society for Magnetic Resonance in Medicine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.26769","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T07:13:10Z","timestamp":1496733190000},"page":"1325-1333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Tomoelastography of the prostate using multifrequency MR elastography and externally placed pressurized\u2010air drivers"],"prefix":"10.1002","volume":"79","author":[{"given":"Florian","family":"Dittmann","sequence":"first","affiliation":[{"name":"Department of Radiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Reiter","sequence":"additional","affiliation":[{"name":"Department of Radiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Radiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Asbach","sequence":"additional","affiliation":[{"name":"Department of Radiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Radiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Braun","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingolf","family":"Sack","sequence":"additional","affiliation":[{"name":"Department of Radiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.08.052"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00117-015-0035-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14140567"},{"key":"e_1_2_6_6_1","first-page":"27","article-title":"WFUMB guidelines and recommendations on the clinical use of ultrasound elastography. 4: Thyroid","volume":"43","author":"Cosgrove D","year":"2016","journal-title":"Ultrasound Med Biol"},{"key":"e_1_2_6_7_1","volume-title":"Magnetic resonance elastography: physical background and medical applications","author":"Hirsch S","year":"2017"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22633"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24028"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23850"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3118"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3218"},{"key":"e_1_2_6_13_1","unstructured":"DittmannF Tzsch\u00e4tzschH GuoJ HirschS BraunJ SackI.In vivo multifrequency MR elastography of the human prostate using a surface\u2010based compressed air driver operated in the lower frequency regime. 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