{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T17:12:22Z","timestamp":1769879542672,"version":"3.49.0"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:00:00Z","timestamp":1498089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>The presence of metallic debris near total hip arthroplasty can have a significant impact on longitudinal patient management. Methods for magnetic resonance imaging\u2010based quantification of metallic debris near painful total hip replacements are described and applied to cohorts of symptomatic and control subject cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A combination of metal artifact reduction, off\u2010resonance mapping, off\u2010resonance background removal, and spatial clustering methods are utilized to quantify off\u2010resonance signatures in cases of suspected metallosis. These methods are applied to a cohort of symptomatic hip arthroplasties composed of cobalt\u2010chromium alloys. Magnetostatic simulations and theoretical principles are used to illuminate the potential sources of the measured off\u2010resonance effects. Reported metrics from histological tissue assays extracted during surgical revision procedures are also correlated with the proposed magnetic resonance imaging\u2010based quantification results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The presented methods identified quantifiable metallosis signatures in more than 70% of the symptomatic and none of the control cases. Preliminary correlations of the MR data with direct histological evaluation of retrieved tissue samples indicate that the observed off\u2010resonance effect may be related to tissue necrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Magnetostatic simulations, theoretical principles, and preliminary histological trends suggest that disassociated cobalt is the source of the observed off\u2010resonance signature. Magn Reson Med 79:1628\u20131637, 2018. \u00a9 2017 International Society for Magnetic Resonance in Medicine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.26807","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T03:36:39Z","timestamp":1498188999000},"page":"1628-1637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Off\u2010resonance based assessment of metallic wear debris near total hip arthroplasty"],"prefix":"10.1002","volume":"79","author":[{"given":"Kevin M.","family":"Koch","sequence":"first","affiliation":[{"name":"Department of Radiology Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew F.","family":"Koff","sequence":"additional","affiliation":[{"name":"Division of Radiology and Imaging Hospital for Special Surgery New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas W.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Anatomic Pathology and Orthopaedic Surgery Cleveland Clinic Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parina H.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Radiology and Imaging Hospital for Special Surgery New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew S.","family":"Nencka","sequence":"additional","affiliation":[{"name":"Department of Radiology Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sivaram Kaushik","sequence":"additional","affiliation":[{"name":"MR Applications and Workflow GE Healthcare Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hollis G.","family":"Potter","sequence":"additional","affiliation":[{"name":"Division of Radiology and Imaging Hospital for Special Surgery New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,22]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"HCUPnet. 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