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The bright\u2010blood datasets are used for both visualization of the coronary lumen and motion estimation, whereas the complementary black\u2010blood dataset potentially allows for thrombus\/hemorrhage visualization. Furthermore, integration with 2D image\u2010based navigation enables 100% scan efficiency and predictable scan times. The proposed sequence was compared to conventional coronary MR angiography (CMRA) and PSIR sequences in a standardized phantom and in healthy subjects. Feasibility for thrombus depiction was tested ex vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      With BOOST, the coronary lumen is visualized with significantly higher (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) contrast\u2010to\u2010noise ratio and vessel sharpness when compared to conventional CMRA. Furthermore, BOOST showed effective blood signal suppression as well as feasibility for thrombus visualization ex vivo.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      A new PSIR sequence for noncontrast enhanced simultaneous coronary lumen and thrombus\/hemorrhage detection was developed. The sequence provided improved coronary lumen depiction and showed potential for thrombus visualization. Magn Reson Med 79:1460\u20131472, 2018. \u00a9 2017 International Society for Magnetic Resonance in Medicine. 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