{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T14:12:50Z","timestamp":1774015970457,"version":"3.50.1"},"reference-count":62,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T00:00:00Z","timestamp":1502755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Metabolite cycling (MC) is an MRS technique for the simultaneous acquisition of water and metabolite spectra that avoids chemical exchange saturation transfer effects and for which water may serve as a reference signal or contain additional information in functional or diffusion studies. Here, MC was developed for human investigations at ultrahigh field.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MC\u2010STEAM and MC\u2010semi\u2010LASER are introduced at 9.4T with an optimized inversion pulse and elaborate coil setup. Experimental and simulation results are given for the implementation of adiabatic inversion pulses for MC. The two techniques are compared, and the effect of frequency and phase correction based on the MC water spectra is evaluated. Finally, absolute quantification of metabolites is performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proposed coil configuration results in a maximum \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm26873-math-0004.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm26873:mrm26873-math-0004\"\/> of 48\u2009\u03bc\u03a4 in a voxel within the occipital lobe. Frequency and phase correction of single acquisitions improve signal\u2010to\u2010noise ratio (SNR) and linewidth, leading to high\u2010resolution spectra. The improvement of SNR of N\u2010acetylaspartate (SNR<jats:sub>NAA<\/jats:sub>) for frequency aligned data, acquired with MC\u2010STEAM and MC\u2010semi\u2010LASER, are 37% and 30%, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Moreover, a doubling of the SNR<jats:sub>NAA<\/jats:sub> for MC\u2010semi\u2010LASER in comparison with MC\u2010STEAM is observed (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Concentration levels for 18 metabolites from the human occipital lobe are reported, as acquired with both MC\u2010STEAM and MC\u2010semi\u2010LASER.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This work introduces a novel methodology for single\u2010voxel MRS on a 9.4T whole\u2010body scanner and highlights the advantages of semi\u2010LASER compared to STEAM in terms of excitation profile. In comparison with MC\u2010STEAM, MC\u2010semi\u2010LASER yields spectra with higher SNR. Magn Reson Med 79:1841\u20131850, 2018. \u00a9 2017 International Society for Magnetic Resonance in Medicine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.26873","type":"journal-article","created":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T04:04:15Z","timestamp":1502856255000},"page":"1841-1850","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Metabolite\u2010cycled STEAM and semi\u2010LASER localization for MR spectroscopy of the human brain at 9.4T"],"prefix":"10.1002","volume":"79","author":[{"given":"Ioannis\u2010Angelos","family":"Giapitzakis","sequence":"first","affiliation":[{"name":"High\u2010Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics T\u00fcbingen Germany"},{"name":"IMPRS for Cognitive &amp; Systems Neuroscience T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Shao","sequence":"additional","affiliation":[{"name":"High\u2010Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolai","family":"Avdievich","sequence":"additional","affiliation":[{"name":"High\u2010Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Mekle","sequence":"additional","affiliation":[{"name":"Center for Stroke Research Berlin (CSB), Charit\u00e9 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Kreis","sequence":"additional","affiliation":[{"name":"Departments of Radiology and Clinical Research University Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke","family":"Henning","sequence":"additional","affiliation":[{"name":"High\u2010Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics T\u00fcbingen Germany"},{"name":"Institute of Physics University of Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23151"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2003.08.027"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22609"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1641"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21961"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.1999.1895"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1213"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21073"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2010.06.006"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24292"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910090110"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21302"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3252"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1727703"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22708"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23288"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1727"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20549"},{"key":"e_1_2_6_20_1","unstructured":"deGraafRA SacolickLO RothmanDL.Water and metabolite\u2010modulated MR spectroscopy and spectroscopic imaging. 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