{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:49:40Z","timestamp":1789422580592,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1R01 AR062581"],"award-info":[{"award-number":["1R01 AR062581"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1R01 AR068987"],"award-info":[{"award-number":["1R01 AR068987"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate high contrast imaging of short T<jats:sub>2<\/jats:sub> tissues with a three\u2010dimensional double adiabatic inversion recovery prepared ultrashort echo time Cones (3D DIR\u2010UTE\u2010Cones) sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The sequence used two sequential adiabatic inversion pulses to suppress signals from long T<jats:sub>2<\/jats:sub> tissues, followed by multispoke UTE acquisition to detect signals from short T<jats:sub>2<\/jats:sub> tissues. The two adiabatic inversion pulses are identical with a center frequency located at the water peak, but the spectral width is broad enough to cover both water and fat frequencies. The feasibility of this technique was demonstrated through numerical simulation and phantom studies. Finally, DIR\u2010UTE\u2010Cones was applied to three healthy volunteers to image cortical bone, patellar tendon, and Achilles tendon. \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm26908-math-0001.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm26908:mrm26908-math-0001\"\/> was also measured via single\u2010component exponential fitting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Numerical simulation suggests that the DIR technique provides perfect nulling of muscle and fat as well as efficient suppression of other long T<jats:sub>2<\/jats:sub> tissues with T<jats:sub>1<\/jats:sub> values between fat and water or those above water. Excellent image contrast can be achieved with DIR\u2010UTE\u2010Cones for the short T<jats:sub>2<\/jats:sub> tissues, with fitted \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm26908-math-0002.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm26908:mrm26908-math-0002\"\/> values of 0.28\u20130.38 ms for cortical bone, 0.56\u2009\u00b1\u20090.07 ms for the patella tendon, and 0.45\u2009\u00b1\u20090.06 ms for the Achilles tendon, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The 3D DIR\u2010UTE\u2010Cones sequence provides robust suppression of long T<jats:sub>2<\/jats:sub> tissues and allows selective imaging as well as \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm26908-math-0003.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm26908:mrm26908-math-0003\"\/> measurement of short T<jats:sub>2<\/jats:sub> tissues such as cortical bone, patellar tendon, and the Achilles tendon. Magn Reson Med 79:2555\u20132563, 2018. \u00a9 2017 International Society for Magnetic Resonance in Medicine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.26908","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T03:54:42Z","timestamp":1505447682000},"page":"2555-2563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Short T<sub>2<\/sub> imaging using a 3D double adiabatic inversion recovery prepared ultrashort echo time cones (3D DIR\u2010UTE\u2010Cones) sequence"],"prefix":"10.1002","volume":"79","author":[{"given":"Ya\u2010Jun","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Radiology University of California San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Carl","sequence":"additional","affiliation":[{"name":"GE Healthcare San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Y.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California San Diego California USA"},{"name":"Radiology Service, VA San Diego Healthcare System San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/crad.2003.1157"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2006.05.014"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23017"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22799"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.2906"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21341"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26160"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20868"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1179"},{"key":"e_1_2_8_12_1","unstructured":"PaulyJM ConollySM MacovskiA.Suppression of long T2 components for short T2 imaging. 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